Intestinal microbiota and ulcerative colitis
Abstract There is a close relationship between the human host and the intestinal microbiota, which is an assortment of microorganisms, protecting the intestine against colonization by exogenous pathogens. Moreover, the intestinal microbiota play a critical role in providing nutrition and the modulat...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2015-11, Vol.21 (11), p.761-768 |
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| container_issue | 11 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Ohkusa, Toshifumi Koido, Shigeo |
| description | Abstract There is a close relationship between the human host and the intestinal microbiota, which is an assortment of microorganisms, protecting the intestine against colonization by exogenous pathogens. Moreover, the intestinal microbiota play a critical role in providing nutrition and the modulation of host immune homeostasis. Recent reports indicate that some strains of intestinal bacteria are responsible for intestinal ulceration and chronic inflammation in inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Understanding the interaction of the intestinal microbiota with pathogens and the human host might provide new strategies treating patients with IBD. This review focuses on the important role that the intestinal microbiota plays in maintaining innate immunity in the pathogenesis and etiology of UC and discusses new antibiotic therapies targeting the intestinal microbiota. |
| doi_str_mv | 10.1016/j.jiac.2015.07.010 |
| format | Article |
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Moreover, the intestinal microbiota play a critical role in providing nutrition and the modulation of host immune homeostasis. Recent reports indicate that some strains of intestinal bacteria are responsible for intestinal ulceration and chronic inflammation in inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Understanding the interaction of the intestinal microbiota with pathogens and the human host might provide new strategies treating patients with IBD. This review focuses on the important role that the intestinal microbiota plays in maintaining innate immunity in the pathogenesis and etiology of UC and discusses new antibiotic therapies targeting the intestinal microbiota.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2015.07.010</identifier><identifier>PMID: 26346678</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Bacteria ; Bacteria - classification ; Bacteria - isolation & purification ; Colitis, Ulcerative - immunology ; Colitis, Ulcerative - microbiology ; Crohn's disease ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunity, Innate ; Inflammatory bowel disease ; Innate immunity ; Intestinal microbiota ; Intestines - immunology ; Intestines - microbiology ; Microbiota ; Ulcerative colitis</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2015-11, Vol.21 (11), p.761-768</ispartof><rights>Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. 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Moreover, the intestinal microbiota play a critical role in providing nutrition and the modulation of host immune homeostasis. Recent reports indicate that some strains of intestinal bacteria are responsible for intestinal ulceration and chronic inflammation in inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Understanding the interaction of the intestinal microbiota with pathogens and the human host might provide new strategies treating patients with IBD. 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| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2015-11, Vol.21 (11), p.761-768 |
| issn | 1341-321X 1437-7780 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bacteria Bacteria - classification Bacteria - isolation & purification Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology Crohn's disease Hematology, Oncology and Palliative Medicine Humans Immunity, Innate Inflammatory bowel disease Innate immunity Intestinal microbiota Intestines - immunology Intestines - microbiology Microbiota Ulcerative colitis |
| title | Intestinal microbiota and ulcerative colitis |
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