Hepatitis B virus core protein inhibits Fas‐mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression

Hepatitis B virus core protein (HBc) has been implicated in hepatocarcinogenesis through several mechanisms. Resistance of hepatitis B virus (HBV)‐infected hepatocytes to apoptosis is considered one of the major contributors to the progression of chronic hepatitis to cirrhosis and ultimately to hepa...

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Veröffentlicht in:	The FASEB journal 2015-03, Vol.29 (3), p.1113-1123
Hauptverfasser:	Liu, Wei, Lin, Yan‐Ting, Yan, Xiao‐Li, Ding, Ya‐Lan, Wu, Yun‐Li, Chen, Wan‐Nan, Lin, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blotting, Western Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Cell Proliferation chronic HBV infection Enzyme-Linked Immunosorbent Assay Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - metabolism FASTK Flow Cytometry Hepatitis B - metabolism Hepatitis B - pathology Hepatitis B - virology Hepatitis B Core Antigens - genetics Hepatitis B Core Antigens - metabolism Hepatitis B virus Hepatitis B virus - physiology Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - virology p53 PTBP1 Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured
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