Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum
Toxicity of human blood serum for ciliate Tetrahymena pyriformis is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease i...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-04, Vol.160 (6), p.775-778 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Ivanov, P. A. Faktor, M. I. Karpova, N. S. Cheremnykh, E. G. Brusov, O. S. |
| description | Toxicity of human blood serum for ciliate
Tetrahymena pyriformis
is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (
e.g
., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with
Tetrahymena
cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible. |
| doi_str_mv | 10.1007/s10517-016-3307-4 |
| format | Article |
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Tetrahymena pyriformis
is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (
e.g
., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with
Tetrahymena
cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3307-4</identifier><identifier>PMID: 27169636</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antiprotozoal Agents - pharmacology ; Biological products ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell Membrane Permeability - drug effects ; Complement Activation ; Complement System Proteins - pharmacology ; Humans ; Internal Medicine ; Laboratory Medicine ; Lectins ; Microbiology and Immunology ; Pathology ; Permeability ; Proteases ; Protein binding ; Serum ; Tetrahymena ; Tetrahymena pyriformis ; Tetrahymena pyriformis - drug effects ; Tetrahymena pyriformis - physiology</subject><ispartof>Bulletin of experimental biology and medicine, 2016-04, Vol.160 (6), p.775-778</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-65bae0f3b15b39fe3f2b3166145a46cc18f9500bf5f40f4fc2a3d79201b3dc4d3</citedby><cites>FETCH-LOGICAL-c503t-65bae0f3b15b39fe3f2b3166145a46cc18f9500bf5f40f4fc2a3d79201b3dc4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-016-3307-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-016-3307-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27169636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanov, P. A.</creatorcontrib><creatorcontrib>Faktor, M. I.</creatorcontrib><creatorcontrib>Karpova, N. S.</creatorcontrib><creatorcontrib>Cheremnykh, E. G.</creatorcontrib><creatorcontrib>Brusov, O. S.</creatorcontrib><title>Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Toxicity of human blood serum for ciliate
Tetrahymena pyriformis
is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (
e.g
., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with
Tetrahymena
cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.</description><subject>Antiprotozoal Agents - pharmacology</subject><subject>Biological products</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Complement Activation</subject><subject>Complement System Proteins - pharmacology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lectins</subject><subject>Microbiology and Immunology</subject><subject>Pathology</subject><subject>Permeability</subject><subject>Proteases</subject><subject>Protein binding</subject><subject>Serum</subject><subject>Tetrahymena</subject><subject>Tetrahymena pyriformis</subject><subject>Tetrahymena pyriformis - drug effects</subject><subject>Tetrahymena pyriformis - physiology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkktv1TAQhS0EoreFH8AGRUJC3aSM7fiRZRseRSpiQRFLy3HGvamS-GIni_vvcXQLtAiEvLB8_M3RzOgQ8oLCGQVQbxIFQVUJVJacgyqrR2RDheKlZow-JhuAVdRaH5HjlG7XJ0j6lBwxRWUtudyQb00YdwOOOM3lJ-x6O2NXvEU7b4vgi6YfVqW4xjna7T5TttjtY-9DHPtUNHZJGW_3xeUy2qm4GELoii8Yl_EZeeLtkPD53X1Cvr5_d91cllefP3xszq9KJ4DPpRStRfC8paLltUfuWcuplLQStpLOUe1rAdB64SvwlXfM8k7VDGjLO1d1_IScHnx3MXxfMM0mN-ZwGOyEYUmGatCKctDwf1TVUElNuc7oqz_Q27DEKQ-SDSXomilW_aZu7ICmn3zIW3KrqTmvhGBaAVeZOvsLlU-HY-_ChL7P-oOC1_cKtmiHeZvCsMx9mNJDkB5AF0NKEb3ZxX60cW8omDUg5hAQkwNi1oCYteeXd5Mt7Yjdr4qficgAOwApf003GO-N_k_XHxcHwbk</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Ivanov, P. 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A.</au><au>Faktor, M. I.</au><au>Karpova, N. S.</au><au>Cheremnykh, E. G.</au><au>Brusov, O. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>160</volume><issue>6</issue><spage>775</spage><epage>778</epage><pages>775-778</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Toxicity of human blood serum for ciliate
Tetrahymena pyriformis
is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (
e.g
., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with
Tetrahymena
cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27169636</pmid><doi>10.1007/s10517-016-3307-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Antiprotozoal Agents - pharmacology Biological products Biomedical and Life Sciences Biomedicine Cell Biology Cell Membrane Permeability - drug effects Complement Activation Complement System Proteins - pharmacology Humans Internal Medicine Laboratory Medicine Lectins Microbiology and Immunology Pathology Permeability Proteases Protein binding Serum Tetrahymena Tetrahymena pyriformis Tetrahymena pyriformis - drug effects Tetrahymena pyriformis - physiology |
| title | Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum |
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