A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation

Abstract Venezuelan equine encephalitis virus (VEEV), a mosquito-borne alphavirus, causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no FDA-licensed vaccines against VEEV. We developed a candidate DNA vaccine expressing the E3-E2-6K-E...

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Veröffentlicht in:	Vaccine 2016-06, Vol.34 (31), p.3607-3612
Hauptverfasser:	Hannaman, Drew, Dupuy, Lesley C, Ellefsen, Barry, Schmaljohn, Connie S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Alphavirus Antibodies, Neutralizing - blood Antibodies, Viral - blood Clinical trial Deoxyribonucleic acid DNA DNA vaccine Double-Blind Method Electroporation Encephalitis Encephalitis Virus, Venezuelan Equine Encephalomyelitis, Venezuelan Equine - prevention & control Female Hispanic Americans Human Humans Immunogenicity Immunogenicity, Vaccine Immunoglobulins Injection Injections, Intradermal Injections, Intramuscular Intradermal Intramuscular Male Middle Aged Phase 1 R&D Reoviridae Research & development Studies Togaviridae Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - therapeutic use Venezuelan equine encephalitis Venezuelan equine encephalitis virus Viral Vaccines - administration & dosage Viral Vaccines - therapeutic use Young Adult
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