Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135

In order to investigate the in vivo dopamine (DA) stimulant properties of selected 3rd generation Spice/K2 cannabinoids, BB-22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at native rat and mice CB1 receptors was studied. The compounds bind with high affinity to CB1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2016-06, Vol.105, p.630-638
Hauptverfasser:	De Luca, Maria Antonietta, Castelli, M. Paola, Loi, Barbara, Porcu, Alessandra, Martorelli, Mariella, Miliano, Cristina, Kellett, Kathryn, Davidson, Colin, Stair, Jacqueline L., Schifano, Fabrizio, Di Chiara, Gaetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Animals Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Antagonists - pharmacology Cannabinoids CB1 receptors Central Nervous System Stimulants - pharmacology Dopamine Dopamine Agents - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical GTPγS binding Indazoles - pharmacology Indoles - pharmacology Male Mice, Inbred C57BL Mice, Knockout Microdialysis Molecular Structure Naphthalenes - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Piperidines - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Pyrazoles - pharmacology Quinolines - pharmacology Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Spice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!