Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus: Bacteriology
To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were...
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| Veröffentlicht in: | Clinical microbiology and infection 2015-12, Vol.21 (12), p.1095.e5-1095.e9 |
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| container_title | Clinical microbiology and infection |
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| creator | Nurjadi, D Schaefer, J Friedrich-Jaenicke, B Mueller, A Neumayr, A Calvo-Cano, A Goorhuis, A Molhoek, N Lagler, H Kantele, A Van Genderen, PJJ Gascon, J Grobusch, M P Caumes, E Hatz, C Fleck, R Mockenhaupt, F P Zanger, P |
| description | To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection. |
| doi_str_mv | 10.1016/j.cmi.2015.08.021 |
| format | Article |
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| ispartof | Clinical microbiology and infection, 2015-12, Vol.21 (12), p.1095.e5-1095.e9 |
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| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Staphylococcus aureus |
| title | Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus: Bacteriology |
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