mRNA-based therapeutics–Advances and perspectives

In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo . Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally...

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Veröffentlicht in:	Biochemistry (Moscow) 2016-07, Vol.81 (7), p.709-722
Hauptverfasser:	Sergeeva, O. V., Koteliansky, V. E., Zatsepin, T. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer immunotherapy Clinical trials Drug Carriers - chemistry Humans Immune response Immune system Immunity, Innate Immunotherapy Infectious diseases Life Sciences Lipids Liposomes - chemistry Microbiology Nanoparticles Nanoparticles - chemistry Neoplasms - immunology Neoplasms - therapy Polymers Review RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Vaccination Vaccines
Online-Zugang:	Volltext
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