mRNA-based therapeutics–Advances and perspectives
In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo . Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally...
Gespeichert in:
| Veröffentlicht in: | Biochemistry (Moscow) 2016-07, Vol.81 (7), p.709-722 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 722 |
|---|---|
| container_issue | 7 |
| container_start_page | 709 |
| container_title | Biochemistry (Moscow) |
| container_volume | 81 |
| creator | Sergeeva, O. V. Koteliansky, V. E. Zatsepin, T. S. |
| description | In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process
in vivo
. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy. |
| doi_str_mv | 10.1134/S0006297916070075 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808709597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A528327556</galeid><sourcerecordid>A528327556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-821e635e111913deb06fae4529c2d86e16d6afd3aa1d261766fb43b63d2c0c303</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS1ExUynPAAbNBIbNple24kdL6OqUKSqlVpYW459UzLKH3YyEjvegTfkSXA0A7RAEfLCP-c7x_fqEvKCwoZSnp7eAoBgSioqQALI7AlZxmOecEjhKVnOcjLrC3IcwjZeGSj-jCyYTFMlqFwS3t5cFUlpArr1-BG9GXAaaxu-fflauJ3pLIa16dx6QB8GtGO9w3BCjirTBHx-2Ffkw5vz92cXyeX123dnxWViM4AxyRlFwTOklCrKHZYgKoNpxpRlLhdIhROmctwY6lgsRoiqTHkpuGMWLAe-Iq_3uYPvP00YRt3WwWLTmA77KWiaQy5BZUr-DypBqpSlEX31G7rtJ9_FRjTLqVSQsVz9i4pZnCtQwH5Rd6ZBXXdVP3pj5691EWM4k1kmIrX5CxWXw7a2fYdVHd8fGOjeYH0fgsdKD75ujf-sKeh58vqPyUfPy0PBU9mi--n4MeoIsD0QotTdob_X0aOp3wFvWLMr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1803390902</pqid></control><display><type>article</type><title>mRNA-based therapeutics–Advances and perspectives</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Sergeeva, O. V. ; Koteliansky, V. E. ; Zatsepin, T. S.</creator><creatorcontrib>Sergeeva, O. V. ; Koteliansky, V. E. ; Zatsepin, T. S.</creatorcontrib><description>In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process
in vivo
. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297916070075</identifier><identifier>PMID: 27449617</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Cancer immunotherapy ; Clinical trials ; Drug Carriers - chemistry ; Humans ; Immune response ; Immune system ; Immunity, Innate ; Immunotherapy ; Infectious diseases ; Life Sciences ; Lipids ; Liposomes - chemistry ; Microbiology ; Nanoparticles ; Nanoparticles - chemistry ; Neoplasms - immunology ; Neoplasms - therapy ; Polymers ; Review ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcription ; Vaccination ; Vaccines</subject><ispartof>Biochemistry (Moscow), 2016-07, Vol.81 (7), p.709-722</ispartof><rights>Pleiades Publishing, Ltd. 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Pleiades Publishing, Ltd. 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-821e635e111913deb06fae4529c2d86e16d6afd3aa1d261766fb43b63d2c0c303</citedby><cites>FETCH-LOGICAL-c500t-821e635e111913deb06fae4529c2d86e16d6afd3aa1d261766fb43b63d2c0c303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297916070075$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297916070075$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27449617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sergeeva, O. V.</creatorcontrib><creatorcontrib>Koteliansky, V. E.</creatorcontrib><creatorcontrib>Zatsepin, T. S.</creatorcontrib><title>mRNA-based therapeutics–Advances and perspectives</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process
in vivo
. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Cancer immunotherapy</subject><subject>Clinical trials</subject><subject>Drug Carriers - chemistry</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>Immunotherapy</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Liposomes - chemistry</subject><subject>Microbiology</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Polymers</subject><subject>Review</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1DAUhS1ExUynPAAbNBIbNple24kdL6OqUKSqlVpYW459UzLKH3YyEjvegTfkSXA0A7RAEfLCP-c7x_fqEvKCwoZSnp7eAoBgSioqQALI7AlZxmOecEjhKVnOcjLrC3IcwjZeGSj-jCyYTFMlqFwS3t5cFUlpArr1-BG9GXAaaxu-fflauJ3pLIa16dx6QB8GtGO9w3BCjirTBHx-2Ffkw5vz92cXyeX123dnxWViM4AxyRlFwTOklCrKHZYgKoNpxpRlLhdIhROmctwY6lgsRoiqTHkpuGMWLAe-Iq_3uYPvP00YRt3WwWLTmA77KWiaQy5BZUr-DypBqpSlEX31G7rtJ9_FRjTLqVSQsVz9i4pZnCtQwH5Rd6ZBXXdVP3pj5691EWM4k1kmIrX5CxWXw7a2fYdVHd8fGOjeYH0fgsdKD75ujf-sKeh58vqPyUfPy0PBU9mi--n4MeoIsD0QotTdob_X0aOp3wFvWLMr</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Sergeeva, O. V.</creator><creator>Koteliansky, V. E.</creator><creator>Zatsepin, T. S.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160701</creationdate><title>mRNA-based therapeutics–Advances and perspectives</title><author>Sergeeva, O. V. ; Koteliansky, V. E. ; Zatsepin, T. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-821e635e111913deb06fae4529c2d86e16d6afd3aa1d261766fb43b63d2c0c303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Cancer immunotherapy</topic><topic>Clinical trials</topic><topic>Drug Carriers - chemistry</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Innate</topic><topic>Immunotherapy</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Liposomes - chemistry</topic><topic>Microbiology</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Polymers</topic><topic>Review</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sergeeva, O. V.</creatorcontrib><creatorcontrib>Koteliansky, V. E.</creatorcontrib><creatorcontrib>Zatsepin, T. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sergeeva, O. V.</au><au>Koteliansky, V. E.</au><au>Zatsepin, T. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mRNA-based therapeutics–Advances and perspectives</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>81</volume><issue>7</issue><spage>709</spage><epage>722</epage><pages>709-722</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process
in vivo
. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>27449617</pmid><doi>10.1134/S0006297916070075</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2979 |
| ispartof | Biochemistry (Moscow), 2016-07, Vol.81 (7), p.709-722 |
| issn | 0006-2979 1608-3040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808709597 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer immunotherapy Clinical trials Drug Carriers - chemistry Humans Immune response Immune system Immunity, Innate Immunotherapy Infectious diseases Life Sciences Lipids Liposomes - chemistry Microbiology Nanoparticles Nanoparticles - chemistry Neoplasms - immunology Neoplasms - therapy Polymers Review RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Vaccination Vaccines |
| title | mRNA-based therapeutics–Advances and perspectives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A07%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=mRNA-based%20therapeutics%E2%80%93Advances%20and%20perspectives&rft.jtitle=Biochemistry%20(Moscow)&rft.au=Sergeeva,%20O.%20V.&rft.date=2016-07-01&rft.volume=81&rft.issue=7&rft.spage=709&rft.epage=722&rft.pages=709-722&rft.issn=0006-2979&rft.eissn=1608-3040&rft_id=info:doi/10.1134/S0006297916070075&rft_dat=%3Cgale_proqu%3EA528327556%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1803390902&rft_id=info:pmid/27449617&rft_galeid=A528327556&rfr_iscdi=true |