Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age
Background Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association of exposure to air pollution during specific trimesters of pregnancy and postnatal life with lung function in preschoolers. Methods Lung function wa...
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| Veröffentlicht in: | Thorax 2015-01, Vol.70 (1), p.64-73 |
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| creator | Morales, Eva Garcia-Esteban, Raquel de la Cruz, Oscar Asensio Basterrechea, Mikel Lertxundi, Aitana de Dicastillo, Maria D Martinez López Zabaleta, Carlos Sunyer, Jordi |
| description | Background Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association of exposure to air pollution during specific trimesters of pregnancy and postnatal life with lung function in preschoolers. Methods Lung function was assessed with spirometry in preschoolers aged 4.5 years (n=620) participating in the INfancia y Medio Ambiente (INMA) cohort. Temporally adjusted land use regression (LUR) models were applied to estimate individual residential exposures to benzene and nitrogen dioxide (NO2) during specific trimesters of pregnancy and early postnatal life (the first year of life). Recent and current (1 year and 1 week before lung function testing, respectively) exposures to NO2 and nitrogen oxides (NOx) were also assessed. Results Exposure to higher levels of benzene and NO2 during pregnancy was associated with reduced lung function. FEV1 estimates for an IQR increase in exposures during the second trimester of pregnancy were −18.4 mL, 95% CI −34.8 to −2.1 for benzene and −28.0 mL, 95% CI −52.9 to −3.2 for NO2. Relative risk (RR) of low lung function ( |
| doi_str_mv | 10.1136/thoraxjnl-2014-205413 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808707952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4025917291</sourcerecordid><originalsourceid>FETCH-LOGICAL-b524t-2165b24cb4e657d4d275adc97b4191c953bd688a5b90521bed19326a6c90e43c3</originalsourceid><addsrcrecordid>eNqNkU1rVDEUhoO02HH0JyiBbtxcm5PPe5dS_CgU3Og6JLmZ9g6ZZMwHtP_ejLd24UY3OeHwvC8kD0JvgXwAYPKq3qdsHvYxDJQA74fgwF6gDXA5DoxO8gxtCOFkkEzJC_SqlD0hZARQL9EFFYwBHWGD_E2s2bTq8xI9NnHG3uTwiI-p1GiqCdg_9HvLHteEU6tzShmbJXcihFaXFH-nQot3eNeiWzcVH7Mv7j6lgM2df43OdyYU_-ZpbtGPz5--X38dbr99ubn-eDtYQXkdKEhhKXeWeynUzGeqhJndpCyHCdwkmJ3lOBphJyIoWD_DxKg00k3Ec-bYFr1fe485_Wy-VH1YivMhmOhTKxpGMiqiJkH_jfZ_E1JxyTp6-Re6Ty3H_hANaoQT1bEtEivlciol-50-5uVg8qMGok_K9LMyfVKmV2U99-6pvdmDn59Tfxx1gKyAPez_s_MX1EOkXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781567446</pqid></control><display><type>article</type><title>Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>Alma/SFX Local Collection</source><creator>Morales, Eva ; Garcia-Esteban, Raquel ; de la Cruz, Oscar Asensio ; Basterrechea, Mikel ; Lertxundi, Aitana ; de Dicastillo, Maria D Martinez López ; Zabaleta, Carlos ; Sunyer, Jordi</creator><creatorcontrib>Morales, Eva ; Garcia-Esteban, Raquel ; de la Cruz, Oscar Asensio ; Basterrechea, Mikel ; Lertxundi, Aitana ; de Dicastillo, Maria D Martinez López ; Zabaleta, Carlos ; Sunyer, Jordi</creatorcontrib><description>Background Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association of exposure to air pollution during specific trimesters of pregnancy and postnatal life with lung function in preschoolers. Methods Lung function was assessed with spirometry in preschoolers aged 4.5 years (n=620) participating in the INfancia y Medio Ambiente (INMA) cohort. Temporally adjusted land use regression (LUR) models were applied to estimate individual residential exposures to benzene and nitrogen dioxide (NO2) during specific trimesters of pregnancy and early postnatal life (the first year of life). Recent and current (1 year and 1 week before lung function testing, respectively) exposures to NO2 and nitrogen oxides (NOx) were also assessed. Results Exposure to higher levels of benzene and NO2 during pregnancy was associated with reduced lung function. FEV1 estimates for an IQR increase in exposures during the second trimester of pregnancy were −18.4 mL, 95% CI −34.8 to −2.1 for benzene and −28.0 mL, 95% CI −52.9 to −3.2 for NO2. Relative risk (RR) of low lung function (<80% of predicted FEV1) for an IQR increase in benzene and NO2 during the second trimester of pregnancy were 1.22, 95% CI 1.02 to 1.46 and 1.30, 95% CI 0.97 to 1.76, respectively. Associations for early postnatal, recent and current exposures were not statistically significant. Stronger associations appeared among allergic children and those of lower social class. Conclusions Prenatal exposure to residential traffic-related air pollution may result in long-term lung function deficits at preschool age.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thoraxjnl-2014-205413</identifier><identifier>PMID: 25331281</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age ; Air Pollutants - adverse effects ; Air pollution ; Child, Preschool ; Environmental Exposure - adverse effects ; Environmental Monitoring ; Female ; Geographic information systems ; Humans ; Hydrocarbons ; Incidence ; Infant ; Infant, Newborn ; Land use ; Male ; Maternal Exposure - adverse effects ; Nitrogen dioxide ; Outdoor air quality ; Pollutants ; Population density ; Pregnancy ; Pregnancy Trimesters ; Prenatal Exposure Delayed Effects - diagnosis ; Prenatal Exposure Delayed Effects - epidemiology ; Respiratory Function Tests ; Respiratory Physiological Phenomena - drug effects ; Spain - epidemiology ; Topography</subject><ispartof>Thorax, 2015-01, Vol.70 (1), p.64-73</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b524t-2165b24cb4e657d4d275adc97b4191c953bd688a5b90521bed19326a6c90e43c3</citedby><cites>FETCH-LOGICAL-b524t-2165b24cb4e657d4d275adc97b4191c953bd688a5b90521bed19326a6c90e43c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/70/1/64.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/70/1/64.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25331281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morales, Eva</creatorcontrib><creatorcontrib>Garcia-Esteban, Raquel</creatorcontrib><creatorcontrib>de la Cruz, Oscar Asensio</creatorcontrib><creatorcontrib>Basterrechea, Mikel</creatorcontrib><creatorcontrib>Lertxundi, Aitana</creatorcontrib><creatorcontrib>de Dicastillo, Maria D Martinez López</creatorcontrib><creatorcontrib>Zabaleta, Carlos</creatorcontrib><creatorcontrib>Sunyer, Jordi</creatorcontrib><title>Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Background Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association of exposure to air pollution during specific trimesters of pregnancy and postnatal life with lung function in preschoolers. Methods Lung function was assessed with spirometry in preschoolers aged 4.5 years (n=620) participating in the INfancia y Medio Ambiente (INMA) cohort. Temporally adjusted land use regression (LUR) models were applied to estimate individual residential exposures to benzene and nitrogen dioxide (NO2) during specific trimesters of pregnancy and early postnatal life (the first year of life). Recent and current (1 year and 1 week before lung function testing, respectively) exposures to NO2 and nitrogen oxides (NOx) were also assessed. Results Exposure to higher levels of benzene and NO2 during pregnancy was associated with reduced lung function. FEV1 estimates for an IQR increase in exposures during the second trimester of pregnancy were −18.4 mL, 95% CI −34.8 to −2.1 for benzene and −28.0 mL, 95% CI −52.9 to −3.2 for NO2. Relative risk (RR) of low lung function (<80% of predicted FEV1) for an IQR increase in benzene and NO2 during the second trimester of pregnancy were 1.22, 95% CI 1.02 to 1.46 and 1.30, 95% CI 0.97 to 1.76, respectively. Associations for early postnatal, recent and current exposures were not statistically significant. Stronger associations appeared among allergic children and those of lower social class. Conclusions Prenatal exposure to residential traffic-related air pollution may result in long-term lung function deficits at preschool age.</description><subject>Adult</subject><subject>Age</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Child, Preschool</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Monitoring</subject><subject>Female</subject><subject>Geographic information systems</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Land use</subject><subject>Male</subject><subject>Maternal Exposure - adverse effects</subject><subject>Nitrogen dioxide</subject><subject>Outdoor air quality</subject><subject>Pollutants</subject><subject>Population density</subject><subject>Pregnancy</subject><subject>Pregnancy Trimesters</subject><subject>Prenatal Exposure Delayed Effects - diagnosis</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Physiological Phenomena - drug effects</subject><subject>Spain - epidemiology</subject><subject>Topography</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1rVDEUhoO02HH0JyiBbtxcm5PPe5dS_CgU3Og6JLmZ9g6ZZMwHtP_ejLd24UY3OeHwvC8kD0JvgXwAYPKq3qdsHvYxDJQA74fgwF6gDXA5DoxO8gxtCOFkkEzJC_SqlD0hZARQL9EFFYwBHWGD_E2s2bTq8xI9NnHG3uTwiI-p1GiqCdg_9HvLHteEU6tzShmbJXcihFaXFH-nQot3eNeiWzcVH7Mv7j6lgM2df43OdyYU_-ZpbtGPz5--X38dbr99ubn-eDtYQXkdKEhhKXeWeynUzGeqhJndpCyHCdwkmJ3lOBphJyIoWD_DxKg00k3Ec-bYFr1fe485_Wy-VH1YivMhmOhTKxpGMiqiJkH_jfZ_E1JxyTp6-Re6Ty3H_hANaoQT1bEtEivlciol-50-5uVg8qMGok_K9LMyfVKmV2U99-6pvdmDn59Tfxx1gKyAPez_s_MX1EOkXw</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Morales, Eva</creator><creator>Garcia-Esteban, Raquel</creator><creator>de la Cruz, Oscar Asensio</creator><creator>Basterrechea, Mikel</creator><creator>Lertxundi, Aitana</creator><creator>de Dicastillo, Maria D Martinez López</creator><creator>Zabaleta, Carlos</creator><creator>Sunyer, Jordi</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20150101</creationdate><title>Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age</title><author>Morales, Eva ; Garcia-Esteban, Raquel ; de la Cruz, Oscar Asensio ; Basterrechea, Mikel ; Lertxundi, Aitana ; de Dicastillo, Maria D Martinez López ; Zabaleta, Carlos ; Sunyer, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b524t-2165b24cb4e657d4d275adc97b4191c953bd688a5b90521bed19326a6c90e43c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Child, Preschool</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Monitoring</topic><topic>Female</topic><topic>Geographic information systems</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Land use</topic><topic>Male</topic><topic>Maternal Exposure - adverse effects</topic><topic>Nitrogen dioxide</topic><topic>Outdoor air quality</topic><topic>Pollutants</topic><topic>Population density</topic><topic>Pregnancy</topic><topic>Pregnancy Trimesters</topic><topic>Prenatal Exposure Delayed Effects - diagnosis</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Physiological Phenomena - drug effects</topic><topic>Spain - epidemiology</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morales, Eva</creatorcontrib><creatorcontrib>Garcia-Esteban, Raquel</creatorcontrib><creatorcontrib>de la Cruz, Oscar Asensio</creatorcontrib><creatorcontrib>Basterrechea, Mikel</creatorcontrib><creatorcontrib>Lertxundi, Aitana</creatorcontrib><creatorcontrib>de Dicastillo, Maria D Martinez López</creatorcontrib><creatorcontrib>Zabaleta, Carlos</creatorcontrib><creatorcontrib>Sunyer, Jordi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morales, Eva</au><au>Garcia-Esteban, Raquel</au><au>de la Cruz, Oscar Asensio</au><au>Basterrechea, Mikel</au><au>Lertxundi, Aitana</au><au>de Dicastillo, Maria D Martinez López</au><au>Zabaleta, Carlos</au><au>Sunyer, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>70</volume><issue>1</issue><spage>64</spage><epage>73</epage><pages>64-73</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>Background Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association of exposure to air pollution during specific trimesters of pregnancy and postnatal life with lung function in preschoolers. Methods Lung function was assessed with spirometry in preschoolers aged 4.5 years (n=620) participating in the INfancia y Medio Ambiente (INMA) cohort. Temporally adjusted land use regression (LUR) models were applied to estimate individual residential exposures to benzene and nitrogen dioxide (NO2) during specific trimesters of pregnancy and early postnatal life (the first year of life). Recent and current (1 year and 1 week before lung function testing, respectively) exposures to NO2 and nitrogen oxides (NOx) were also assessed. Results Exposure to higher levels of benzene and NO2 during pregnancy was associated with reduced lung function. FEV1 estimates for an IQR increase in exposures during the second trimester of pregnancy were −18.4 mL, 95% CI −34.8 to −2.1 for benzene and −28.0 mL, 95% CI −52.9 to −3.2 for NO2. Relative risk (RR) of low lung function (<80% of predicted FEV1) for an IQR increase in benzene and NO2 during the second trimester of pregnancy were 1.22, 95% CI 1.02 to 1.46 and 1.30, 95% CI 0.97 to 1.76, respectively. Associations for early postnatal, recent and current exposures were not statistically significant. Stronger associations appeared among allergic children and those of lower social class. Conclusions Prenatal exposure to residential traffic-related air pollution may result in long-term lung function deficits at preschool age.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25331281</pmid><doi>10.1136/thoraxjnl-2014-205413</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Air Pollutants - adverse effects Air pollution Child, Preschool Environmental Exposure - adverse effects Environmental Monitoring Female Geographic information systems Humans Hydrocarbons Incidence Infant Infant, Newborn Land use Male Maternal Exposure - adverse effects Nitrogen dioxide Outdoor air quality Pollutants Population density Pregnancy Pregnancy Trimesters Prenatal Exposure Delayed Effects - diagnosis Prenatal Exposure Delayed Effects - epidemiology Respiratory Function Tests Respiratory Physiological Phenomena - drug effects Spain - epidemiology Topography |
| title | Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age |
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