BRCA1‐like profile predicts benefit of tandem high dose epirubicin‐cyclophospamide‐thiotepa in high risk breast cancer patients randomized in the WSG‐AM01 trial

BRCA1 is an important protein in the repair of DNA double strand breaks (DSBs), which are induced by alkylating chemotherapy. A BRCA1‐like DNA copy number signature derived from tumors with a BRCA1 mutation is indicative for impaired BRCA1 function and associated with good outcome after high dose (H...

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Veröffentlicht in:	International journal of cancer 2016-08, Vol.139 (4), p.882-889
Hauptverfasser:	Schouten, Philip C., Gluz, Oleg, Harbeck, Nadia, Mohrmann, Svjetlana, Diallo‐Danebrock, Raihana, Pelz, Enrico, Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Liedtke, Cornelia, Frick, Markus, Kates, Ronald, Linn, Sabine C., Nitz, Ulrike, Marme, Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged alkylating chemotherapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor BRCA1 BRCA1 Protein - genetics BRCA1 Protein - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Chemotherapy Clinical trials copy number profiling Cyclophosphamide - administration & dosage Epirubicin - administration & dosage Female Humans Medical research Middle Aged Neoplasm Grading predictive biomarker Prognosis Proteins Survival Analysis Thiotepa - administration & dosage Treatment Outcome
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