Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: A fast road to remission?
Abstract Although accelerated repetitive Transcranial Magnetic Stimulation (rTMS) paradigms and intermittent Theta-burst Stimulation (iTBS) may have the potency to result in superior clinical outcomes in Treatment Resistant Depression (TRD), accelerated iTBS treatment has not yet been studied. In th...
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| Veröffentlicht in: | Journal of affective disorders 2016-08, Vol.200, p.6-14 |
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| creator | Duprat, Romain Desmyter, Stefanie Rudi, De Raedt van Heeringen, Kees Van den Abbeele, Dirk Tandt, Hannelore Bakic, Jasmina Pourtois, Gilles Dedoncker, Josefien Vervaet, Myriam Van Autreve, Sara Lemmens, Gilbert M.D Baeken, Chris |
| description | Abstract Although accelerated repetitive Transcranial Magnetic Stimulation (rTMS) paradigms and intermittent Theta-burst Stimulation (iTBS) may have the potency to result in superior clinical outcomes in Treatment Resistant Depression (TRD), accelerated iTBS treatment has not yet been studied. In this registered randomized double-blind sham-controlled crossover study, spread over four successive days, 50 TRD patients received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (DLPFC). The accelerated iTBS treatment procedure was found to be safe and resulted in immediate statistically significant decreases in depressive symptoms regardless of order/type of stimulation (real/sham). While only 28% of the patients showed a 50% reduction of their initial Hamilton Depression Rating Scale score at the end of the two-week procedure, this response rate increased to 38% when assessed two weeks after the end of the sham-controlled iTBS protocol, indicating delayed clinical effects. Importantly, 30% of the responders were considered in clinical remission. We found no demographic predictors for response. Our findings indicate that only four days of accelerated iTBS treatment applied to the left DLPFC in TRD may lead to meaningful clinical responses within two weeks post stimulation. |
| doi_str_mv | 10.1016/j.jad.2016.04.015 |
| format | Article |
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In this registered randomized double-blind sham-controlled crossover study, spread over four successive days, 50 TRD patients received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (DLPFC). The accelerated iTBS treatment procedure was found to be safe and resulted in immediate statistically significant decreases in depressive symptoms regardless of order/type of stimulation (real/sham). While only 28% of the patients showed a 50% reduction of their initial Hamilton Depression Rating Scale score at the end of the two-week procedure, this response rate increased to 38% when assessed two weeks after the end of the sham-controlled iTBS protocol, indicating delayed clinical effects. Importantly, 30% of the responders were considered in clinical remission. We found no demographic predictors for response. Our findings indicate that only four days of accelerated iTBS treatment applied to the left DLPFC in TRD may lead to meaningful clinical responses within two weeks post stimulation.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2016.04.015</identifier><identifier>PMID: 27107779</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Accelerated rTMS ; Adult ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols ; Cross-Over Studies ; Cytarabine ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Depressive Disorder, Major - therapy ; Depressive Disorder, Treatment-Resistant - physiopathology ; Depressive Disorder, Treatment-Resistant - psychology ; Depressive Disorder, Treatment-Resistant - therapy ; Double-Blind Method ; Female ; Humans ; Intermittent theta-burst stimulation ; Left DLPFC ; Major depression ; Male ; Middle Aged ; Mitoxantrone ; Prefrontal Cortex - physiopathology ; Psychiatry ; Theta Rhythm - physiology ; Transcranial Magnetic Stimulation - methods ; Treatment Outcome ; Treatment resistance</subject><ispartof>Journal of affective disorders, 2016-08, Vol.200, p.6-14</ispartof><rights>Elsevier B.V.</rights><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-ecc36159b3d6f799e06265ddbdec30c3ce539ab48a05dda38cb6fa68beefb69b3</citedby><cites>FETCH-LOGICAL-c507t-ecc36159b3d6f799e06265ddbdec30c3ce539ab48a05dda38cb6fa68beefb69b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032715314440$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27107779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duprat, Romain</creatorcontrib><creatorcontrib>Desmyter, Stefanie</creatorcontrib><creatorcontrib>Rudi, De Raedt</creatorcontrib><creatorcontrib>van Heeringen, Kees</creatorcontrib><creatorcontrib>Van den Abbeele, Dirk</creatorcontrib><creatorcontrib>Tandt, Hannelore</creatorcontrib><creatorcontrib>Bakic, Jasmina</creatorcontrib><creatorcontrib>Pourtois, Gilles</creatorcontrib><creatorcontrib>Dedoncker, Josefien</creatorcontrib><creatorcontrib>Vervaet, Myriam</creatorcontrib><creatorcontrib>Van Autreve, Sara</creatorcontrib><creatorcontrib>Lemmens, Gilbert M.D</creatorcontrib><creatorcontrib>Baeken, Chris</creatorcontrib><title>Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: A fast road to remission?</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Although accelerated repetitive Transcranial Magnetic Stimulation (rTMS) paradigms and intermittent Theta-burst Stimulation (iTBS) may have the potency to result in superior clinical outcomes in Treatment Resistant Depression (TRD), accelerated iTBS treatment has not yet been studied. In this registered randomized double-blind sham-controlled crossover study, spread over four successive days, 50 TRD patients received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (DLPFC). The accelerated iTBS treatment procedure was found to be safe and resulted in immediate statistically significant decreases in depressive symptoms regardless of order/type of stimulation (real/sham). While only 28% of the patients showed a 50% reduction of their initial Hamilton Depression Rating Scale score at the end of the two-week procedure, this response rate increased to 38% when assessed two weeks after the end of the sham-controlled iTBS protocol, indicating delayed clinical effects. Importantly, 30% of the responders were considered in clinical remission. We found no demographic predictors for response. Our findings indicate that only four days of accelerated iTBS treatment applied to the left DLPFC in TRD may lead to meaningful clinical responses within two weeks post stimulation.</description><subject>Accelerated rTMS</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Cross-Over Studies</subject><subject>Cytarabine</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Depressive Disorder, Treatment-Resistant - physiopathology</subject><subject>Depressive Disorder, Treatment-Resistant - psychology</subject><subject>Depressive Disorder, Treatment-Resistant - therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Intermittent theta-burst stimulation</subject><subject>Left DLPFC</subject><subject>Major depression</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitoxantrone</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatry</subject><subject>Theta Rhythm - physiology</subject><subject>Transcranial Magnetic Stimulation - methods</subject><subject>Treatment Outcome</subject><subject>Treatment resistance</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAUtBCILoUfwAX5yCXhOU7sDUhUq4oWpEocgLPl2C_CIR-L7SD1wm_npVs4cICTrXkzI3vmMfZcQClAqFdDOVhfVnQtoS5BNA_YTjRaFlUj9EO2o0FTgKz0GXuS0gAAqtXwmJ1VWoDWut2xnwfncMRoM3oe5oxxCjnjnHn-itnybo0p85TDtI42h2XmOaLN08YIM5_QB3eHFxFTSNkSPtlhidzjkaBEo9f8wHtLNnGxnueFR5zC3eTiKXvU2zHhs_vznH25evf58n1x8_H6w-XhpnAN6Fygc1KJpu2kV71uWwRVqcb7zqOT4KTDRra2q_cWCLVy7zrVW7XvEPtOkeycvTz5HuPyfcWUDb2APj7aGZc1GbGHvQYlG_l_qm5lJapWbVRxorq4pBSxN8cYJhtvjQCzNWQGQw2ZrSEDtaGGSPPi3n7tKL0_it-VEOHNiYCUx4-A0SQXcHaUdESXjV_CP-3f_qV2Y5ipo_Eb3mIaljXOFLQRJlUGzKdtRbYNIamo6xrkL2uxuX8</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Duprat, Romain</creator><creator>Desmyter, Stefanie</creator><creator>Rudi, De Raedt</creator><creator>van Heeringen, Kees</creator><creator>Van den Abbeele, Dirk</creator><creator>Tandt, Hannelore</creator><creator>Bakic, Jasmina</creator><creator>Pourtois, Gilles</creator><creator>Dedoncker, Josefien</creator><creator>Vervaet, Myriam</creator><creator>Van Autreve, Sara</creator><creator>Lemmens, Gilbert M.D</creator><creator>Baeken, Chris</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160801</creationdate><title>Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: A fast road to remission?</title><author>Duprat, Romain ; Desmyter, Stefanie ; Rudi, De Raedt ; van Heeringen, Kees ; Van den Abbeele, Dirk ; Tandt, Hannelore ; Bakic, Jasmina ; Pourtois, Gilles ; Dedoncker, Josefien ; Vervaet, Myriam ; Van Autreve, Sara ; Lemmens, Gilbert M.D ; Baeken, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-ecc36159b3d6f799e06265ddbdec30c3ce539ab48a05dda38cb6fa68beefb69b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Accelerated rTMS</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Cross-Over Studies</topic><topic>Cytarabine</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Depressive Disorder, Treatment-Resistant - physiopathology</topic><topic>Depressive Disorder, Treatment-Resistant - psychology</topic><topic>Depressive Disorder, Treatment-Resistant - therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Intermittent theta-burst stimulation</topic><topic>Left DLPFC</topic><topic>Major depression</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitoxantrone</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatry</topic><topic>Theta Rhythm - physiology</topic><topic>Transcranial Magnetic Stimulation - methods</topic><topic>Treatment Outcome</topic><topic>Treatment resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duprat, Romain</creatorcontrib><creatorcontrib>Desmyter, Stefanie</creatorcontrib><creatorcontrib>Rudi, De Raedt</creatorcontrib><creatorcontrib>van Heeringen, Kees</creatorcontrib><creatorcontrib>Van den Abbeele, Dirk</creatorcontrib><creatorcontrib>Tandt, Hannelore</creatorcontrib><creatorcontrib>Bakic, Jasmina</creatorcontrib><creatorcontrib>Pourtois, Gilles</creatorcontrib><creatorcontrib>Dedoncker, Josefien</creatorcontrib><creatorcontrib>Vervaet, Myriam</creatorcontrib><creatorcontrib>Van Autreve, Sara</creatorcontrib><creatorcontrib>Lemmens, Gilbert M.D</creatorcontrib><creatorcontrib>Baeken, Chris</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duprat, Romain</au><au>Desmyter, Stefanie</au><au>Rudi, De Raedt</au><au>van Heeringen, Kees</au><au>Van den Abbeele, Dirk</au><au>Tandt, Hannelore</au><au>Bakic, Jasmina</au><au>Pourtois, Gilles</au><au>Dedoncker, Josefien</au><au>Vervaet, Myriam</au><au>Van Autreve, Sara</au><au>Lemmens, Gilbert M.D</au><au>Baeken, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: A fast road to remission?</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>200</volume><spage>6</spage><epage>14</epage><pages>6-14</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>Abstract Although accelerated repetitive Transcranial Magnetic Stimulation (rTMS) paradigms and intermittent Theta-burst Stimulation (iTBS) may have the potency to result in superior clinical outcomes in Treatment Resistant Depression (TRD), accelerated iTBS treatment has not yet been studied. In this registered randomized double-blind sham-controlled crossover study, spread over four successive days, 50 TRD patients received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (DLPFC). The accelerated iTBS treatment procedure was found to be safe and resulted in immediate statistically significant decreases in depressive symptoms regardless of order/type of stimulation (real/sham). While only 28% of the patients showed a 50% reduction of their initial Hamilton Depression Rating Scale score at the end of the two-week procedure, this response rate increased to 38% when assessed two weeks after the end of the sham-controlled iTBS protocol, indicating delayed clinical effects. Importantly, 30% of the responders were considered in clinical remission. We found no demographic predictors for response. Our findings indicate that only four days of accelerated iTBS treatment applied to the left DLPFC in TRD may lead to meaningful clinical responses within two weeks post stimulation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27107779</pmid><doi>10.1016/j.jad.2016.04.015</doi><tpages>9</tpages></addata></record> |
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| subjects | Accelerated rTMS Adult Age Factors Antineoplastic Combined Chemotherapy Protocols Cross-Over Studies Cytarabine Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Depressive Disorder, Major - therapy Depressive Disorder, Treatment-Resistant - physiopathology Depressive Disorder, Treatment-Resistant - psychology Depressive Disorder, Treatment-Resistant - therapy Double-Blind Method Female Humans Intermittent theta-burst stimulation Left DLPFC Major depression Male Middle Aged Mitoxantrone Prefrontal Cortex - physiopathology Psychiatry Theta Rhythm - physiology Transcranial Magnetic Stimulation - methods Treatment Outcome Treatment resistance |
| title | Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: A fast road to remission? |
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