Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines

Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influe...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-11, Vol.193 (9), p.4335-4343
Hauptverfasser:	Yu, Chun I, Becker, Christian, Metang, Patrick, Marches, Florentina, Wang, Yuanyuan, Toshiyuki, Hori, Banchereau, Jacques, Merad, Miriam, Palucka, A Karolina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1 - metabolism Antigens, Surface - metabolism CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD40 Antigens - metabolism Cell Differentiation Cells, Cultured Cytokines - biosynthesis Dendritic Cells - immunology Dendritic Cells - metabolism Glycoproteins - metabolism Humans Immunophenotyping Influenza virus Lung - immunology Lung - metabolism Lung - virology Lymphocyte Activation - immunology Mice Mice, Knockout Orthomyxoviridae - immunology OX40 Ligand - metabolism Phenotype Signal Transduction Th2 Cells - immunology Th2 Cells - metabolism
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