Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines
Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influe...
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| Veröffentlicht in: | The Journal of immunology (1950) 2014-11, Vol.193 (9), p.4335-4343 |
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| container_end_page | 4343 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 193 |
| creator | Yu, Chun I Becker, Christian Metang, Patrick Marches, Florentina Wang, Yuanyuan Toshiyuki, Hori Banchereau, Jacques Merad, Miriam Palucka, A Karolina |
| description | Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses. |
| doi_str_mv | 10.4049/jimmunol.1401159 |
| format | Article |
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In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.1401159</identifier><identifier>PMID: 25246496</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antigens, CD1 - metabolism ; Antigens, Surface - metabolism ; CD4-Positive T-Lymphocytes - cytology ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - metabolism ; CD40 Antigens - metabolism ; Cell Differentiation ; Cells, Cultured ; Cytokines - biosynthesis ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Glycoproteins - metabolism ; Humans ; Immunophenotyping ; Influenza virus ; Lung - immunology ; Lung - metabolism ; Lung - virology ; Lymphocyte Activation - immunology ; Mice ; Mice, Knockout ; Orthomyxoviridae - immunology ; OX40 Ligand - metabolism ; Phenotype ; Signal Transduction ; Th2 Cells - immunology ; Th2 Cells - metabolism</subject><ispartof>The Journal of immunology (1950), 2014-11, Vol.193 (9), p.4335-4343</ispartof><rights>Copyright © 2014 by The American Association of Immunologists, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-37070efc895d878b32f8bed321fa81d829d66258d108c842003133720d80fadf3</citedby><cites>FETCH-LOGICAL-c374t-37070efc895d878b32f8bed321fa81d829d66258d108c842003133720d80fadf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25246496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Chun I</creatorcontrib><creatorcontrib>Becker, Christian</creatorcontrib><creatorcontrib>Metang, Patrick</creatorcontrib><creatorcontrib>Marches, Florentina</creatorcontrib><creatorcontrib>Wang, Yuanyuan</creatorcontrib><creatorcontrib>Toshiyuki, Hori</creatorcontrib><creatorcontrib>Banchereau, Jacques</creatorcontrib><creatorcontrib>Merad, Miriam</creatorcontrib><creatorcontrib>Palucka, A Karolina</creatorcontrib><title>Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.</description><subject>Animals</subject><subject>Antigens, CD1 - metabolism</subject><subject>Antigens, Surface - metabolism</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD40 Antigens - metabolism</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Cytokines - biosynthesis</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Glycoproteins - metabolism</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Influenza virus</subject><subject>Lung - immunology</subject><subject>Lung - metabolism</subject><subject>Lung - virology</subject><subject>Lymphocyte Activation - immunology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Orthomyxoviridae - immunology</subject><subject>OX40 Ligand - metabolism</subject><subject>Phenotype</subject><subject>Signal Transduction</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAUxC0EoqWwMyGPSFXKe7ZjOyNqgSJVYilzlPpDcslHiZOh_z0tTVmZnnTv7nT6EXKPMBMgsqdtqKq-bsoZCkBMswsyxjSFREqQl2QMwFiCSqoRuYlxCwASmLgmI5YyIUUmx2S17KuipvMFCpxS62rbhi4YalxZRhpq2xt3-IopXQ9a19Bd2_zq3X7nKKNm3zVfoXbxllz5oozubrgT8vn6sp4vk9XH2_v8eZUYrkSXcAUKnDc6S61WesOZ1xtnOUNfaLSaZVZKlmqLoI0WDIAj54qB1eAL6_mEPJ56D0O-exe7vArxuK6oXdPHHDVoBZxJ8b9VIs8Ex_RohZPVtE2MrfP5rg1V0e5zhPyIOz_jzgfch8jD0N5vKmf_Ame-_Acm7XmT</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Yu, Chun I</creator><creator>Becker, Christian</creator><creator>Metang, Patrick</creator><creator>Marches, Florentina</creator><creator>Wang, Yuanyuan</creator><creator>Toshiyuki, Hori</creator><creator>Banchereau, Jacques</creator><creator>Merad, Miriam</creator><creator>Palucka, A Karolina</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20141101</creationdate><title>Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines</title><author>Yu, Chun I ; Becker, Christian ; Metang, Patrick ; Marches, Florentina ; Wang, Yuanyuan ; Toshiyuki, Hori ; Banchereau, Jacques ; Merad, Miriam ; Palucka, A Karolina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-37070efc895d878b32f8bed321fa81d829d66258d108c842003133720d80fadf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antigens, CD1 - metabolism</topic><topic>Antigens, Surface - metabolism</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD40 Antigens - metabolism</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Cytokines - biosynthesis</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Glycoproteins - metabolism</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Influenza virus</topic><topic>Lung - immunology</topic><topic>Lung - metabolism</topic><topic>Lung - virology</topic><topic>Lymphocyte Activation - immunology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Orthomyxoviridae - immunology</topic><topic>OX40 Ligand - metabolism</topic><topic>Phenotype</topic><topic>Signal Transduction</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Chun I</creatorcontrib><creatorcontrib>Becker, Christian</creatorcontrib><creatorcontrib>Metang, Patrick</creatorcontrib><creatorcontrib>Marches, Florentina</creatorcontrib><creatorcontrib>Wang, Yuanyuan</creatorcontrib><creatorcontrib>Toshiyuki, Hori</creatorcontrib><creatorcontrib>Banchereau, Jacques</creatorcontrib><creatorcontrib>Merad, Miriam</creatorcontrib><creatorcontrib>Palucka, A Karolina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Chun I</au><au>Becker, Christian</au><au>Metang, Patrick</au><au>Marches, Florentina</au><au>Wang, Yuanyuan</au><au>Toshiyuki, Hori</au><au>Banchereau, Jacques</au><au>Merad, Miriam</au><au>Palucka, A Karolina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>193</volume><issue>9</issue><spage>4335</spage><epage>4343</epage><pages>4335-4343</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.</abstract><cop>United States</cop><pmid>25246496</pmid><doi>10.4049/jimmunol.1401159</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens, CD1 - metabolism Antigens, Surface - metabolism CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD40 Antigens - metabolism Cell Differentiation Cells, Cultured Cytokines - biosynthesis Dendritic Cells - immunology Dendritic Cells - metabolism Glycoproteins - metabolism Humans Immunophenotyping Influenza virus Lung - immunology Lung - metabolism Lung - virology Lymphocyte Activation - immunology Mice Mice, Knockout Orthomyxoviridae - immunology OX40 Ligand - metabolism Phenotype Signal Transduction Th2 Cells - immunology Th2 Cells - metabolism |
| title | Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines |
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