Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer
Abstract Background Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as significant predictor for poor prognosis of various malignant tumors. In this study, we evaluated...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016-05, Vol.16 (3), p.434-440 |
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| creator | Asaoka, Tadafumi Miyamoto, Atsushi Maeda, Sakae Tsujie, Masanori Hama, Naoki Yamamoto, Kazuyoshi Miyake, Masakazu Haraguchi, Naotsugu Nishikawa, Kazuhiro Hirao, Motohiro Ikeda, Masataka Sekimoto, Mitsugu Nakamori, Shoji |
| description | Abstract Background Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as significant predictor for poor prognosis of various malignant tumors. In this study, we evaluated the prognostic values of these preoperative parameters in patients with resectable pancreatic head cancer. Methods We retrospectively reviewed consecutive patients who underwent PD for pancreatic head cancer between 2007 and 2012. A total of 46 patients were enrolled in this analysis. Preoperative parameters such as CRP, CA19-9, NLR and PNI at the time of presentation were recorded as well as overall survival. Cancer specific survival was assessed using Kaplan–Meier method. Univariate and multivariate Cox regression models were applied to evaluate the prognostic relevance of preoperative parameters. The correlations between CA19-9 values, NLR and pathological findings, first recurrence site were respectively reviewed. Results In multivariable analysis preoperative high NLR (≧2.7) and high CA19-9 (≧230) were independent prognostic factors for poor survival (P value: 0.03 and 0.025, respectively). Kaplan–Meier survival analysis demonstrated the overall 2-year survival rate in patients with high NLR or high CA19-9 were 37.5% compared with 89.9% in patients with low NLR and low CA19-9. Conclusion Preoperative NLR and serum CA19-9 offer significant prognostic information associated with overall survival following PD in the patients with pancreatic head cancer. |
| doi_str_mv | 10.1016/j.pan.2015.10.006 |
| format | Article |
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In this study, we evaluated the prognostic values of these preoperative parameters in patients with resectable pancreatic head cancer. Methods We retrospectively reviewed consecutive patients who underwent PD for pancreatic head cancer between 2007 and 2012. A total of 46 patients were enrolled in this analysis. Preoperative parameters such as CRP, CA19-9, NLR and PNI at the time of presentation were recorded as well as overall survival. Cancer specific survival was assessed using Kaplan–Meier method. Univariate and multivariate Cox regression models were applied to evaluate the prognostic relevance of preoperative parameters. The correlations between CA19-9 values, NLR and pathological findings, first recurrence site were respectively reviewed. Results In multivariable analysis preoperative high NLR (≧2.7) and high CA19-9 (≧230) were independent prognostic factors for poor survival (P value: 0.03 and 0.025, respectively). Kaplan–Meier survival analysis demonstrated the overall 2-year survival rate in patients with high NLR or high CA19-9 were 37.5% compared with 89.9% in patients with low NLR and low CA19-9. Conclusion Preoperative NLR and serum CA19-9 offer significant prognostic information associated with overall survival following PD in the patients with pancreatic head cancer.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2015.10.006</identifier><identifier>PMID: 26852169</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Aged ; CA-19-9 Antigen - blood ; CA19-9 ; Cancer therapies ; Carcinoma, Pancreatic Ductal - blood ; Carcinoma, Pancreatic Ductal - diagnosis ; Carcinoma, Pancreatic Ductal - mortality ; Carcinoma, Pancreatic Ductal - surgery ; Chemotherapy ; Endocrinology & Metabolism ; Female ; Follow-Up Studies ; Gastroenterology and Hepatology ; Humans ; Lymphatic system ; Lymphocyte Count ; Lymphocytes ; Lymphocytes - metabolism ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Multivariate analysis ; Neoadjuvant chemotherapy ; Neutrophil-to-lymphocyte ratio (NLR) ; Neutrophils - metabolism ; Pancreatic cancer ; Pancreatic head cancer ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy ; Pancreatoduodenectomy ; Predictive Value of Tests ; Preoperative Care ; Preoperative Period ; Prognosis ; Retrospective Studies ; Surgery ; Survival Analysis ; Tumors</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2016-05, Vol.16 (3), p.434-440</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier B.V.</rights><rights>Copyright Elsevier Limited May/Jun 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-e8dce97b80847f4e3b9f370af47a80dc241d668c72eeab2b5d2bbc4958def0cb3</citedby><cites>FETCH-LOGICAL-c535t-e8dce97b80847f4e3b9f370af47a80dc241d668c72eeab2b5d2bbc4958def0cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26852169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Miyamoto, Atsushi</creatorcontrib><creatorcontrib>Maeda, Sakae</creatorcontrib><creatorcontrib>Tsujie, Masanori</creatorcontrib><creatorcontrib>Hama, Naoki</creatorcontrib><creatorcontrib>Yamamoto, Kazuyoshi</creatorcontrib><creatorcontrib>Miyake, Masakazu</creatorcontrib><creatorcontrib>Haraguchi, Naotsugu</creatorcontrib><creatorcontrib>Nishikawa, Kazuhiro</creatorcontrib><creatorcontrib>Hirao, Motohiro</creatorcontrib><creatorcontrib>Ikeda, Masataka</creatorcontrib><creatorcontrib>Sekimoto, Mitsugu</creatorcontrib><creatorcontrib>Nakamori, Shoji</creatorcontrib><title>Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Abstract Background Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as significant predictor for poor prognosis of various malignant tumors. In this study, we evaluated the prognostic values of these preoperative parameters in patients with resectable pancreatic head cancer. Methods We retrospectively reviewed consecutive patients who underwent PD for pancreatic head cancer between 2007 and 2012. A total of 46 patients were enrolled in this analysis. Preoperative parameters such as CRP, CA19-9, NLR and PNI at the time of presentation were recorded as well as overall survival. Cancer specific survival was assessed using Kaplan–Meier method. Univariate and multivariate Cox regression models were applied to evaluate the prognostic relevance of preoperative parameters. The correlations between CA19-9 values, NLR and pathological findings, first recurrence site were respectively reviewed. Results In multivariable analysis preoperative high NLR (≧2.7) and high CA19-9 (≧230) were independent prognostic factors for poor survival (P value: 0.03 and 0.025, respectively). Kaplan–Meier survival analysis demonstrated the overall 2-year survival rate in patients with high NLR or high CA19-9 were 37.5% compared with 89.9% in patients with low NLR and low CA19-9. Conclusion Preoperative NLR and serum CA19-9 offer significant prognostic information associated with overall survival following PD in the patients with pancreatic head cancer.</description><subject>Aged</subject><subject>CA-19-9 Antigen - blood</subject><subject>CA19-9</subject><subject>Cancer therapies</subject><subject>Carcinoma, Pancreatic Ductal - blood</subject><subject>Carcinoma, Pancreatic Ductal - diagnosis</subject><subject>Carcinoma, Pancreatic Ductal - mortality</subject><subject>Carcinoma, Pancreatic Ductal - surgery</subject><subject>Chemotherapy</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoadjuvant chemotherapy</subject><subject>Neutrophil-to-lymphocyte ratio (NLR)</subject><subject>Neutrophils - metabolism</subject><subject>Pancreatic cancer</subject><subject>Pancreatic head cancer</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy</subject><subject>Pancreatoduodenectomy</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9r3DAQxUVpadKkH6CXYuglF29HkmVZFAphSZrAkoT8OQtZGhdtvZYreQP59pHZJIUc0pNG4veemDdDyBcKCwq0_r5ejGZYMKAi3xcA9TuyTytWlVxR-v6lBr5HPqW0BmCMUvWR7LG6EYzWap-cXMXwewhp8rbwm9HYqQhdMUYMI0Yz-XssLlbXhRlcsTymqlSFH4r8q41oZo3NJcZD8qEzfcLPT-cBuTs9uV2elavLX-fL41VpBRdTiY2zqGTbQFPJrkLeqo5LMF0lTQPOsoq6um6sZIimZa1wrG1tpUTjsAPb8gNytPMdY_i7xTTpjU8W-94MGLZJ0-wsgefW_o9KxQRvAGRGv71C12Ebh9zITIlsySuWKbqjbAwpRez0GP3GxAdNQc_j0Gudg9HzOOanPI6s-frkvG036F4Uz_ln4McOwJzavceok_WYI3U-op20C_5N-5-v1Lb3g7em_4MPmP51oRPToG_mfZjXgYqslnXNHwFMm60X</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Asaoka, Tadafumi</creator><creator>Miyamoto, Atsushi</creator><creator>Maeda, Sakae</creator><creator>Tsujie, Masanori</creator><creator>Hama, Naoki</creator><creator>Yamamoto, Kazuyoshi</creator><creator>Miyake, Masakazu</creator><creator>Haraguchi, Naotsugu</creator><creator>Nishikawa, Kazuhiro</creator><creator>Hirao, Motohiro</creator><creator>Ikeda, Masataka</creator><creator>Sekimoto, Mitsugu</creator><creator>Nakamori, Shoji</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer</title><author>Asaoka, Tadafumi ; Miyamoto, Atsushi ; Maeda, Sakae ; Tsujie, Masanori ; Hama, Naoki ; Yamamoto, Kazuyoshi ; Miyake, Masakazu ; Haraguchi, Naotsugu ; Nishikawa, Kazuhiro ; Hirao, Motohiro ; Ikeda, Masataka ; Sekimoto, Mitsugu ; Nakamori, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-e8dce97b80847f4e3b9f370af47a80dc241d668c72eeab2b5d2bbc4958def0cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>CA-19-9 Antigen - blood</topic><topic>CA19-9</topic><topic>Cancer therapies</topic><topic>Carcinoma, Pancreatic Ductal - blood</topic><topic>Carcinoma, Pancreatic Ductal - diagnosis</topic><topic>Carcinoma, Pancreatic Ductal - mortality</topic><topic>Carcinoma, Pancreatic Ductal - surgery</topic><topic>Chemotherapy</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoadjuvant chemotherapy</topic><topic>Neutrophil-to-lymphocyte ratio (NLR)</topic><topic>Neutrophils - metabolism</topic><topic>Pancreatic cancer</topic><topic>Pancreatic head cancer</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreaticoduodenectomy</topic><topic>Pancreatoduodenectomy</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Miyamoto, Atsushi</creatorcontrib><creatorcontrib>Maeda, Sakae</creatorcontrib><creatorcontrib>Tsujie, Masanori</creatorcontrib><creatorcontrib>Hama, Naoki</creatorcontrib><creatorcontrib>Yamamoto, Kazuyoshi</creatorcontrib><creatorcontrib>Miyake, Masakazu</creatorcontrib><creatorcontrib>Haraguchi, Naotsugu</creatorcontrib><creatorcontrib>Nishikawa, Kazuhiro</creatorcontrib><creatorcontrib>Hirao, Motohiro</creatorcontrib><creatorcontrib>Ikeda, Masataka</creatorcontrib><creatorcontrib>Sekimoto, Mitsugu</creatorcontrib><creatorcontrib>Nakamori, Shoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asaoka, Tadafumi</au><au>Miyamoto, Atsushi</au><au>Maeda, Sakae</au><au>Tsujie, Masanori</au><au>Hama, Naoki</au><au>Yamamoto, Kazuyoshi</au><au>Miyake, Masakazu</au><au>Haraguchi, Naotsugu</au><au>Nishikawa, Kazuhiro</au><au>Hirao, Motohiro</au><au>Ikeda, Masataka</au><au>Sekimoto, Mitsugu</au><au>Nakamori, Shoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>16</volume><issue>3</issue><spage>434</spage><epage>440</epage><pages>434-440</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Abstract Background Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as significant predictor for poor prognosis of various malignant tumors. In this study, we evaluated the prognostic values of these preoperative parameters in patients with resectable pancreatic head cancer. Methods We retrospectively reviewed consecutive patients who underwent PD for pancreatic head cancer between 2007 and 2012. A total of 46 patients were enrolled in this analysis. Preoperative parameters such as CRP, CA19-9, NLR and PNI at the time of presentation were recorded as well as overall survival. Cancer specific survival was assessed using Kaplan–Meier method. Univariate and multivariate Cox regression models were applied to evaluate the prognostic relevance of preoperative parameters. The correlations between CA19-9 values, NLR and pathological findings, first recurrence site were respectively reviewed. Results In multivariable analysis preoperative high NLR (≧2.7) and high CA19-9 (≧230) were independent prognostic factors for poor survival (P value: 0.03 and 0.025, respectively). Kaplan–Meier survival analysis demonstrated the overall 2-year survival rate in patients with high NLR or high CA19-9 were 37.5% compared with 89.9% in patients with low NLR and low CA19-9. Conclusion Preoperative NLR and serum CA19-9 offer significant prognostic information associated with overall survival following PD in the patients with pancreatic head cancer.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>26852169</pmid><doi>10.1016/j.pan.2015.10.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged CA-19-9 Antigen - blood CA19-9 Cancer therapies Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - surgery Chemotherapy Endocrinology & Metabolism Female Follow-Up Studies Gastroenterology and Hepatology Humans Lymphatic system Lymphocyte Count Lymphocytes Lymphocytes - metabolism Male Medical prognosis Metastasis Middle Aged Multivariate analysis Neoadjuvant chemotherapy Neutrophil-to-lymphocyte ratio (NLR) Neutrophils - metabolism Pancreatic cancer Pancreatic head cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - mortality Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Pancreatoduodenectomy Predictive Value of Tests Preoperative Care Preoperative Period Prognosis Retrospective Studies Surgery Survival Analysis Tumors |
| title | Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer |
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