Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice

Abstract Myeloid differentiation factor 88(MyD88) is an endogenous adaptor protein that plays an important role in coordinating intracellular inflammatory responses induced by agonists of the Toll-like receptor and interleukin-1 receptor families. MyD88 has been reported to be essential for neuronal...

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Veröffentlicht in:	Brain research 2016-07, Vol.1643, p.130-139
Hauptverfasser:	Zhang, Hua-sheng, Li, Hua, Zhang, Ding-ding, Yan, Hui-ying, Zhang, Zi-huan, Zhou, Chen-hui, Ye, Zhen-nan, Chen, Qiang, Jiang, Tian-wei, Liu, Jing-peng, Hang, Chun-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Brain - drug effects Brain - metabolism Brain - pathology Brain Edema - etiology Brain Edema - prevention & control Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - pathology Brain Injuries, Traumatic - prevention & control Cytokines - metabolism Disease Models, Animal Encephalitis - etiology Encephalitis - metabolism Encephalitis - prevention & control Heterocyclic Compounds, 2-Ring - administration & dosage Male MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred ICR Myeloid differentiation factor 88 Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - metabolism Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - administration & dosage Spiro Compounds - administration & dosage ST2825 Traumatic brain injury Zonula Occludens-1 Protein - metabolism
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