PT-07 PINEALOBLASTOMAS
OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul...
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| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2014-11, Vol.16 (suppl 5), p.v176-v176 |
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| container_issue | suppl 5 |
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| container_title | Neuro-oncology (Charlottesville, Va.) |
| container_volume | 16 |
| creator | Kebudi, R. Koc, B. Agaoglu, F. Y. Gorgun, O. Wolff, J. Kapu, S. B. Kebudi, A. Cak r, F. B. Darendeliler, E. |
| description | OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul University, Oncology Institute were evaluated retrospectively for demographic data, treatment and long term outcome. RESULTS: During 1990-2012, 6 children (3 male, 3 female) with a median age of 6 years (2 years- 14 years), were diagnosed with pinealoblastoma, in the Istanbul University, Oncology Institute. At the same time interval 494 patients |
| doi_str_mv | 10.1093/neuonc/nou266.7 |
| format | Article |
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Y. ; Gorgun, O. ; Wolff, J. ; Kapu, S. B. ; Kebudi, A. ; Cak r, F. B. ; Darendeliler, E.</creator><creatorcontrib>Kebudi, R. ; Koc, B. ; Agaoglu, F. Y. ; Gorgun, O. ; Wolff, J. ; Kapu, S. B. ; Kebudi, A. ; Cak r, F. B. ; Darendeliler, E.</creatorcontrib><description>OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul University, Oncology Institute were evaluated retrospectively for demographic data, treatment and long term outcome. RESULTS: During 1990-2012, 6 children (3 male, 3 female) with a median age of 6 years (2 years- 14 years), were diagnosed with pinealoblastoma, in the Istanbul University, Oncology Institute. At the same time interval 494 patients <19 years old were diagnosed with malignant central nervous system (CNS) tumors in the same center, thus pinealoblastomas constituted 1. 2 % of all CNS tumors. Three had subotal resection and three underwent a biopsy. At diagnosis, one had spinal seeding both in MRI and cerebrospinal fluid cytology. All received craniospinal radiotherapy and chemotherapy, the patient < 3 years old received neoadjuvant chemotherapy first. The median follow up is 5 years (1-9.5 years). Two patients are alive for 5.5 and 10 years. One has just had a total thyroidectomy for papillary thyroid cancer as a second malignancy at 9.5 years. All others have died at a median of 2.7 years due to progressive disease. CONCLUSIONS: In conclusion, PBL are aggressive tumors necessitating intensive treatment strategies including surgery, craniospinal radiotherapy and chemotherapy. Patients should be followed up for long term side effects such as second malignancies.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/nou266.7</identifier><language>eng</language><ispartof>Neuro-oncology (Charlottesville, Va.), 2014-11, Vol.16 (suppl 5), p.v176-v176</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kebudi, R.</creatorcontrib><creatorcontrib>Koc, B.</creatorcontrib><creatorcontrib>Agaoglu, F. Y.</creatorcontrib><creatorcontrib>Gorgun, O.</creatorcontrib><creatorcontrib>Wolff, J.</creatorcontrib><creatorcontrib>Kapu, S. B.</creatorcontrib><creatorcontrib>Kebudi, A.</creatorcontrib><creatorcontrib>Cak r, F. B.</creatorcontrib><creatorcontrib>Darendeliler, E.</creatorcontrib><title>PT-07 PINEALOBLASTOMAS</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul University, Oncology Institute were evaluated retrospectively for demographic data, treatment and long term outcome. RESULTS: During 1990-2012, 6 children (3 male, 3 female) with a median age of 6 years (2 years- 14 years), were diagnosed with pinealoblastoma, in the Istanbul University, Oncology Institute. At the same time interval 494 patients <19 years old were diagnosed with malignant central nervous system (CNS) tumors in the same center, thus pinealoblastomas constituted 1. 2 % of all CNS tumors. Three had subotal resection and three underwent a biopsy. At diagnosis, one had spinal seeding both in MRI and cerebrospinal fluid cytology. All received craniospinal radiotherapy and chemotherapy, the patient < 3 years old received neoadjuvant chemotherapy first. The median follow up is 5 years (1-9.5 years). Two patients are alive for 5.5 and 10 years. One has just had a total thyroidectomy for papillary thyroid cancer as a second malignancy at 9.5 years. All others have died at a median of 2.7 years due to progressive disease. CONCLUSIONS: In conclusion, PBL are aggressive tumors necessitating intensive treatment strategies including surgery, craniospinal radiotherapy and chemotherapy. Patients should be followed up for long term side effects such as second malignancies.</description><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNotkD1PwzAURS0EEqWwwsrI4uY9O_4aQ9VCpbSp1DBbTmJLRWlSYjLw71EJ073D0RkOIU8ICwTDk86PfVcnXT8yKRfqisxQME6FlvL67zOqBapbchfjJwBDIXFGHvclBfW83-xWWV685tmhLLbZ4Z7cBNdG__C_c_KxXpXLd5oXb5tlltMaMVW0ckyp4LAKzmCjhG9kGmSDRoDmtQMvTTBca2GMw5ByrxADMG2gkiI0hs_Jy-Q9D_3X6OO3PR1j7dvWdb4fo0UNWgFL5QVNJrQe-hgHH-x5OJ7c8GMR7KWAnQrYqYBV_BcVSkzp</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Kebudi, R.</creator><creator>Koc, B.</creator><creator>Agaoglu, F. Y.</creator><creator>Gorgun, O.</creator><creator>Wolff, J.</creator><creator>Kapu, S. B.</creator><creator>Kebudi, A.</creator><creator>Cak r, F. B.</creator><creator>Darendeliler, E.</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20141101</creationdate><title>PT-07 PINEALOBLASTOMAS</title><author>Kebudi, R. ; Koc, B. ; Agaoglu, F. Y. ; Gorgun, O. ; Wolff, J. ; Kapu, S. B. ; Kebudi, A. ; Cak r, F. B. ; Darendeliler, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1147-ba277fa1bfa91d75ed64f6d195083ca0e69f9388599a1f43e711f02890b65fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kebudi, R.</creatorcontrib><creatorcontrib>Koc, B.</creatorcontrib><creatorcontrib>Agaoglu, F. Y.</creatorcontrib><creatorcontrib>Gorgun, O.</creatorcontrib><creatorcontrib>Wolff, J.</creatorcontrib><creatorcontrib>Kapu, S. B.</creatorcontrib><creatorcontrib>Kebudi, A.</creatorcontrib><creatorcontrib>Cak r, F. B.</creatorcontrib><creatorcontrib>Darendeliler, E.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kebudi, R.</au><au>Koc, B.</au><au>Agaoglu, F. Y.</au><au>Gorgun, O.</au><au>Wolff, J.</au><au>Kapu, S. B.</au><au>Kebudi, A.</au><au>Cak r, F. B.</au><au>Darendeliler, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PT-07 PINEALOBLASTOMAS</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2014-11-01</date><risdate>2014</risdate><volume>16</volume><issue>suppl 5</issue><spage>v176</spage><epage>v176</epage><pages>v176-v176</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul University, Oncology Institute were evaluated retrospectively for demographic data, treatment and long term outcome. RESULTS: During 1990-2012, 6 children (3 male, 3 female) with a median age of 6 years (2 years- 14 years), were diagnosed with pinealoblastoma, in the Istanbul University, Oncology Institute. At the same time interval 494 patients <19 years old were diagnosed with malignant central nervous system (CNS) tumors in the same center, thus pinealoblastomas constituted 1. 2 % of all CNS tumors. Three had subotal resection and three underwent a biopsy. At diagnosis, one had spinal seeding both in MRI and cerebrospinal fluid cytology. All received craniospinal radiotherapy and chemotherapy, the patient < 3 years old received neoadjuvant chemotherapy first. The median follow up is 5 years (1-9.5 years). Two patients are alive for 5.5 and 10 years. One has just had a total thyroidectomy for papillary thyroid cancer as a second malignancy at 9.5 years. All others have died at a median of 2.7 years due to progressive disease. CONCLUSIONS: In conclusion, PBL are aggressive tumors necessitating intensive treatment strategies including surgery, craniospinal radiotherapy and chemotherapy. Patients should be followed up for long term side effects such as second malignancies.</abstract><doi>10.1093/neuonc/nou266.7</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| title | PT-07 PINEALOBLASTOMAS |
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