A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect Against Mycobacterium abscessus

Recent studies have demonstrated the therapeutic potential of mesenchymal stem cells (MSCs) for the treatment of acute inflammatory injury and bacterial pneumonia, but their therapeutic applications in mycobacterial infections have not been investigated. In this study, we demonstrated the use of MSC...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2016-07, Vol.34 (7), p.1957-1970
Hauptverfasser:	Kim, Jong‐Seok, Cha, Sang‐Ho, Kim, Woo Sik, Han, Seung Jung, Cha, Seung Bin, Kim, Hong Min, Kwon, Kee Woong, Kim, So Jeong, Choi, Hong‐Hee, Lee, Jienny, Cho, Sang‐Nae, Koh, Won‐Jung, Park, Yeong‐Min, Shin, Sung Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD11b antigen CD4 antigen CD8 antigen Cell activation Cell Communication - drug effects Cell interactions Cellular therapy Cytokines Cytokines - biosynthesis Dinoprostone - metabolism Drug resistance Guanidines - pharmacology Infections Inflammation Injection Interleukin 6 Intravenous administration Lungs Lymphocytes Lymphocytes T Macrophages Macrophages - drug effects Macrophages - metabolism Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Mice, Inbred C57BL Monocyte chemoattractant protein 1 Mycobacterium Mycobacterium abscessus Mycobacterium abscessus - drug effects Mycobacterium abscessus - growth & development Mycobacterium abscessus - physiology Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium Infections, Nontuberculous - pathology Mycobacterium Infections, Nontuberculous - therapy NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide - biosynthesis Pneumonia Prostaglandin E2 Signal Transduction - drug effects Spleen Stem cell transplantation Stem cells Stem cell‐microenvironment interactions Survival Analysis Therapeutic applications Tumor necrosis factor-α Up-Regulation - drug effects γ-Interferon
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