Red cell and platelet transfusions in neonates: a population-based study
ObjectivesThis study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates.DesignLinked population-based birth and hospital data from New...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2015-09, Vol.100 (5), p.F411-F415 |
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| container_title | Archives of disease in childhood. Fetal and neonatal edition |
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| creator | Bowen, Jennifer R Patterson, Jillian A Roberts, Christine L Isbister, James P Irving, David O Ford, Jane B |
| description | ObjectivesThis study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates.DesignLinked population-based birth and hospital data from New South Wales (NSW), Australia, were used to determine rates of blood product transfusion in the first 28 days of life. The study included all live births ≥23 weeks’ gestation in NSW between 2001 and 2011.ResultsBetween 2001 and 2011, 5326 of 989 491 live born neonates received a red cell, platelet or exchange transfusion (5.4/1000 births). Transfusion rates were 4.8 per 1000 for red cells, 1.3 per 1000 for platelets and 0.3 per 1000 for exchange transfusion. Overall transfusion rate remained constant from 2001 to 2011 (p=0.27). Among transfused neonates, 60% were |
| doi_str_mv | 10.1136/archdischild-2014-307716 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808700739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1732092086</sourcerecordid><originalsourceid>FETCH-LOGICAL-b523t-fa2d99224eca31f3054cad4db970c0c5486f37aa944205c0a2478cd98c09a82c3</originalsourceid><addsrcrecordid>eNqNkU9LxDAQxYMorq5-BQl48VKd_GsSbyLqCoIgei5pkrJdum1t2sN-e2dZFfGipwyZ35vkzSOEMrhkTORXbvDLUCe_rJuQcWAyE6A1y_fIEZO5wSvF97EWymbcWjMjxymtAIBprQ_JjCurNc_VEVm8xEB9bBrq2kD7xo2xiSMdB9emakp11yZat7SNXYutdE0d7bt-Qg5bWekSytM4hc0JOahck-Lp5zknb_d3r7eL7On54fH25ikrFRdjVjkerOVcRu8EqwQo6V2QobQaPHglTV4J7ZyVEk14cFxq44M1Hqwz3Is5udjN7YfufYppLNa4CDTg8I9TKpgBowG0sH-jWnCwHEz-DxQU0pIBoue_0FU3DS16RsqAVKCYQsrsKD90KQ2xKvqhXrthUzAothkWPzMsthkWuwxRevb5wFSuY_gWfoWGgNgB5Xr1_7EfqLCqJQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780450515</pqid></control><display><type>article</type><title>Red cell and platelet transfusions in neonates: a population-based study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Bowen, Jennifer R ; Patterson, Jillian A ; Roberts, Christine L ; Isbister, James P ; Irving, David O ; Ford, Jane B</creator><creatorcontrib>Bowen, Jennifer R ; Patterson, Jillian A ; Roberts, Christine L ; Isbister, James P ; Irving, David O ; Ford, Jane B</creatorcontrib><description>ObjectivesThis study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates.DesignLinked population-based birth and hospital data from New South Wales (NSW), Australia, were used to determine rates of blood product transfusion in the first 28 days of life. The study included all live births ≥23 weeks’ gestation in NSW between 2001 and 2011.ResultsBetween 2001 and 2011, 5326 of 989 491 live born neonates received a red cell, platelet or exchange transfusion (5.4/1000 births). Transfusion rates were 4.8 per 1000 for red cells, 1.3 per 1000 for platelets and 0.3 per 1000 for exchange transfusion. Overall transfusion rate remained constant from 2001 to 2011 (p=0.27). Among transfused neonates, 60% were <32 weeks' gestation (n=3210, 331/1000 births), 40% were ≥32 weeks' gestation (n= 2116, 2/1000 births) and 7% received transfusions in a hospital without a neonatal intensive care unit (NICU). Factors other than prematurity associated with higher transfusion rates were prior in utero transfusion (631/1000), congenital anomaly requiring surgery (440/1000) and haemolytic disorder (106/1000).ConclusionsIn this population-based study, preterm neonates had a higher rate of transfusion than term neonates; however, 40% of those who received a transfusion were born ≥32 weeks' gestation and 7% were transfused in hospitals without an NICU. These findings need to be considered by transfusion services and personnel developing neonatal transfusion guidelines.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/archdischild-2014-307716</identifier><identifier>PMID: 25977265</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Age ; Birth weight ; Births ; Blood platelets ; Blood products ; Blood transfusions ; Congenital Abnormalities - therapy ; Congenital diseases ; Data collection ; Datasets ; Erythrocyte Transfusion - statistics & numerical data ; Erythrocyte Transfusion - trends ; Exchange Transfusion, Whole Blood - statistics & numerical data ; Exchange Transfusion, Whole Blood - trends ; Gestational Age ; Hematologic Diseases - therapy ; Hospitals ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - therapy ; Intensive care ; Neonates ; New South Wales ; Platelet Transfusion - statistics & numerical data ; Platelet Transfusion - trends ; Population ; Population studies ; Pregnancy ; Premature birth ; Risk Factors ; Surgery ; Transfusion ; Trends ; Ventilation</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2015-09, Vol.100 (5), p.F411-F415</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b523t-fa2d99224eca31f3054cad4db970c0c5486f37aa944205c0a2478cd98c09a82c3</citedby><cites>FETCH-LOGICAL-b523t-fa2d99224eca31f3054cad4db970c0c5486f37aa944205c0a2478cd98c09a82c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://fn.bmj.com/content/100/5/F411.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://fn.bmj.com/content/100/5/F411.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25977265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowen, Jennifer R</creatorcontrib><creatorcontrib>Patterson, Jillian A</creatorcontrib><creatorcontrib>Roberts, Christine L</creatorcontrib><creatorcontrib>Isbister, James P</creatorcontrib><creatorcontrib>Irving, David O</creatorcontrib><creatorcontrib>Ford, Jane B</creatorcontrib><title>Red cell and platelet transfusions in neonates: a population-based study</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>ObjectivesThis study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates.DesignLinked population-based birth and hospital data from New South Wales (NSW), Australia, were used to determine rates of blood product transfusion in the first 28 days of life. The study included all live births ≥23 weeks’ gestation in NSW between 2001 and 2011.ResultsBetween 2001 and 2011, 5326 of 989 491 live born neonates received a red cell, platelet or exchange transfusion (5.4/1000 births). Transfusion rates were 4.8 per 1000 for red cells, 1.3 per 1000 for platelets and 0.3 per 1000 for exchange transfusion. Overall transfusion rate remained constant from 2001 to 2011 (p=0.27). Among transfused neonates, 60% were <32 weeks' gestation (n=3210, 331/1000 births), 40% were ≥32 weeks' gestation (n= 2116, 2/1000 births) and 7% received transfusions in a hospital without a neonatal intensive care unit (NICU). Factors other than prematurity associated with higher transfusion rates were prior in utero transfusion (631/1000), congenital anomaly requiring surgery (440/1000) and haemolytic disorder (106/1000).ConclusionsIn this population-based study, preterm neonates had a higher rate of transfusion than term neonates; however, 40% of those who received a transfusion were born ≥32 weeks' gestation and 7% were transfused in hospitals without an NICU. These findings need to be considered by transfusion services and personnel developing neonatal transfusion guidelines.</description><subject>Age</subject><subject>Birth weight</subject><subject>Births</subject><subject>Blood platelets</subject><subject>Blood products</subject><subject>Blood transfusions</subject><subject>Congenital Abnormalities - therapy</subject><subject>Congenital diseases</subject><subject>Data collection</subject><subject>Datasets</subject><subject>Erythrocyte Transfusion - statistics & numerical data</subject><subject>Erythrocyte Transfusion - trends</subject><subject>Exchange Transfusion, Whole Blood - statistics & numerical data</subject><subject>Exchange Transfusion, Whole Blood - trends</subject><subject>Gestational Age</subject><subject>Hematologic Diseases - therapy</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - therapy</subject><subject>Intensive care</subject><subject>Neonates</subject><subject>New South Wales</subject><subject>Platelet Transfusion - statistics & numerical data</subject><subject>Platelet Transfusion - trends</subject><subject>Population</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Transfusion</subject><subject>Trends</subject><subject>Ventilation</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU9LxDAQxYMorq5-BQl48VKd_GsSbyLqCoIgei5pkrJdum1t2sN-e2dZFfGipwyZ35vkzSOEMrhkTORXbvDLUCe_rJuQcWAyE6A1y_fIEZO5wSvF97EWymbcWjMjxymtAIBprQ_JjCurNc_VEVm8xEB9bBrq2kD7xo2xiSMdB9emakp11yZat7SNXYutdE0d7bt-Qg5bWekSytM4hc0JOahck-Lp5zknb_d3r7eL7On54fH25ikrFRdjVjkerOVcRu8EqwQo6V2QobQaPHglTV4J7ZyVEk14cFxq44M1Hqwz3Is5udjN7YfufYppLNa4CDTg8I9TKpgBowG0sH-jWnCwHEz-DxQU0pIBoue_0FU3DS16RsqAVKCYQsrsKD90KQ2xKvqhXrthUzAothkWPzMsthkWuwxRevb5wFSuY_gWfoWGgNgB5Xr1_7EfqLCqJQ</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Bowen, Jennifer R</creator><creator>Patterson, Jillian A</creator><creator>Roberts, Christine L</creator><creator>Isbister, James P</creator><creator>Irving, David O</creator><creator>Ford, Jane B</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150901</creationdate><title>Red cell and platelet transfusions in neonates: a population-based study</title><author>Bowen, Jennifer R ; Patterson, Jillian A ; Roberts, Christine L ; Isbister, James P ; Irving, David O ; Ford, Jane B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b523t-fa2d99224eca31f3054cad4db970c0c5486f37aa944205c0a2478cd98c09a82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Birth weight</topic><topic>Births</topic><topic>Blood platelets</topic><topic>Blood products</topic><topic>Blood transfusions</topic><topic>Congenital Abnormalities - therapy</topic><topic>Congenital diseases</topic><topic>Data collection</topic><topic>Datasets</topic><topic>Erythrocyte Transfusion - statistics & numerical data</topic><topic>Erythrocyte Transfusion - trends</topic><topic>Exchange Transfusion, Whole Blood - statistics & numerical data</topic><topic>Exchange Transfusion, Whole Blood - trends</topic><topic>Gestational Age</topic><topic>Hematologic Diseases - therapy</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - therapy</topic><topic>Intensive care</topic><topic>Neonates</topic><topic>New South Wales</topic><topic>Platelet Transfusion - statistics & numerical data</topic><topic>Platelet Transfusion - trends</topic><topic>Population</topic><topic>Population studies</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Transfusion</topic><topic>Trends</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowen, Jennifer R</creatorcontrib><creatorcontrib>Patterson, Jillian A</creatorcontrib><creatorcontrib>Roberts, Christine L</creatorcontrib><creatorcontrib>Isbister, James P</creatorcontrib><creatorcontrib>Irving, David O</creatorcontrib><creatorcontrib>Ford, Jane B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowen, Jennifer R</au><au>Patterson, Jillian A</au><au>Roberts, Christine L</au><au>Isbister, James P</au><au>Irving, David O</au><au>Ford, Jane B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red cell and platelet transfusions in neonates: a population-based study</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>100</volume><issue>5</issue><spage>F411</spage><epage>F415</epage><pages>F411-F415</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>ObjectivesThis study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates.DesignLinked population-based birth and hospital data from New South Wales (NSW), Australia, were used to determine rates of blood product transfusion in the first 28 days of life. The study included all live births ≥23 weeks’ gestation in NSW between 2001 and 2011.ResultsBetween 2001 and 2011, 5326 of 989 491 live born neonates received a red cell, platelet or exchange transfusion (5.4/1000 births). Transfusion rates were 4.8 per 1000 for red cells, 1.3 per 1000 for platelets and 0.3 per 1000 for exchange transfusion. Overall transfusion rate remained constant from 2001 to 2011 (p=0.27). Among transfused neonates, 60% were <32 weeks' gestation (n=3210, 331/1000 births), 40% were ≥32 weeks' gestation (n= 2116, 2/1000 births) and 7% received transfusions in a hospital without a neonatal intensive care unit (NICU). Factors other than prematurity associated with higher transfusion rates were prior in utero transfusion (631/1000), congenital anomaly requiring surgery (440/1000) and haemolytic disorder (106/1000).ConclusionsIn this population-based study, preterm neonates had a higher rate of transfusion than term neonates; however, 40% of those who received a transfusion were born ≥32 weeks' gestation and 7% were transfused in hospitals without an NICU. These findings need to be considered by transfusion services and personnel developing neonatal transfusion guidelines.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25977265</pmid><doi>10.1136/archdischild-2014-307716</doi></addata></record> |
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| ispartof | Archives of disease in childhood. Fetal and neonatal edition, 2015-09, Vol.100 (5), p.F411-F415 |
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| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Age Birth weight Births Blood platelets Blood products Blood transfusions Congenital Abnormalities - therapy Congenital diseases Data collection Datasets Erythrocyte Transfusion - statistics & numerical data Erythrocyte Transfusion - trends Exchange Transfusion, Whole Blood - statistics & numerical data Exchange Transfusion, Whole Blood - trends Gestational Age Hematologic Diseases - therapy Hospitals Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - therapy Intensive care Neonates New South Wales Platelet Transfusion - statistics & numerical data Platelet Transfusion - trends Population Population studies Pregnancy Premature birth Risk Factors Surgery Transfusion Trends Ventilation |
| title | Red cell and platelet transfusions in neonates: a population-based study |
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