Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development

Wnt signaling has been implicated in T cell development. However, it remained unclear which cell type is the major source of Wnt ligands and to what extent thymic epithelial cell (TEC) development is dependent on Wnt signaling. In this study, we analyzed the role of Wnt ligands provided by TECs for...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-12, Vol.195 (11), p.5261-5271
Hauptverfasser:	Brunk, Fabian, Augustin, Iris, Meister, Michael, Boutros, Michael, Kyewski, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - immunology Epithelial Cells - immunology Forkhead Transcription Factors - genetics Intracellular Signaling Peptides and Proteins - genetics Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Receptors, G-Protein-Coupled - genetics T-Lymphocytes - cytology T-Lymphocytes - immunology Thymus Gland - immunology Wnt Proteins - metabolism Wnt Proteins - secretion Wnt Signaling Pathway - immunology
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