Adult asthma increases dementia risk: a nationwide cohort study
Background Studies on the association between adult asthma and dementia are few. We investigated the risk of dementia in patients diagnosed with adult asthma compared with that of people without asthma who were age and sex matched to the study patients. Methods We used data from the National Health...
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| Veröffentlicht in: | Journal of epidemiology and community health (1979) 2015-02, Vol.69 (2), p.123-128 |
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| container_title | Journal of epidemiology and community health (1979) |
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| creator | Peng, Yi-Hao Wu, Biing-Ru Su, Ching-Hua Liao, Wei-Chih Muo, Chih-Hsin Hsia, Te-Chun Kao, Chia-Hung |
| description | Background Studies on the association between adult asthma and dementia are few. We investigated the risk of dementia in patients diagnosed with adult asthma compared with that of people without asthma who were age and sex matched to the study patients. Methods We used data from the National Health Insurance Research Database. A total of 12 771 patients with newly diagnosed asthma between 2001 and 2003 were evaluated and 51 084 people without asthma were used as the comparison cohort. Cox proportional hazard regression analysis was used to measure the HR of dementia for the asthmatic cohort, compared with that of the non-asthmatic cohort. Results The HR of dementia was 1.27 (95% confidence interval (CI) 1.15 to 1.41) for the asthmatic cohort, compared with the non-asthmatic cohort after adjusting for age, sex, comorbidities, annual outpatient department visits and medicine used. The HR of dementia development increased substantially as frequency of asthma exacerbation and hospitalisation increased. Conclusions This nationwide cohort study suggests that the risk of dementia development is significantly increased in patients with asthma compared with that of the general population. In addition, dementia risk increases substantially with asthma exacerbation and hospitalisation frequency increases. |
| doi_str_mv | 10.1136/jech-2014-204445 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808699981</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>43281881</jstor_id><sourcerecordid>43281881</sourcerecordid><originalsourceid>FETCH-LOGICAL-b418t-dab36ecdb4da11c073219e8e360ae9a185f40fb432e2c607941adec685e677863</originalsourceid><addsrcrecordid>eNqFkc1r2zAYxkXZWNNu9102DLsUiju9sqyPXkoIbVco9NLBbkKW3hB7sZ1JMiX__Zy4zaGXXCTB83s_9DyEfAV6BVCInw26Vc4o8PHgnJcnZAZc0pzJQn0gs1EockrLP6fkLMaGjk_J9CdyykomgXE9IzdzP6xTZmNatTarOxfQRoyZxxa7VNss1PHvdWazzqa6715qj5nrV31IWUyD334mH5d2HfHL631Oft_dPi9-5Y9P9w-L-WNecVAp97YqBDpfcW8BHJUFA40KC0EtaguqXHK6rHjBkDlBpeZgPTqhShRSKlGck4up7yb0_waMybR1dLhe2w77IRpQVAmttYLjqCgZpwB79Mc7tOmH0I0fMSClZqpUSo4UnSgX-hgDLs0m1K0NWwPU7HIwuxzMLgcz5TCWfH9tPFQt-kPBm_Ej8G0Cmpj6cNBHAxSo_WaXk161zfFx_wE2LJj7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779285887</pqid></control><display><type>article</type><title>Adult asthma increases dementia risk: a nationwide cohort study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>Jstor Complete Legacy</source><creator>Peng, Yi-Hao ; Wu, Biing-Ru ; Su, Ching-Hua ; Liao, Wei-Chih ; Muo, Chih-Hsin ; Hsia, Te-Chun ; Kao, Chia-Hung</creator><creatorcontrib>Peng, Yi-Hao ; Wu, Biing-Ru ; Su, Ching-Hua ; Liao, Wei-Chih ; Muo, Chih-Hsin ; Hsia, Te-Chun ; Kao, Chia-Hung</creatorcontrib><description>Background Studies on the association between adult asthma and dementia are few. We investigated the risk of dementia in patients diagnosed with adult asthma compared with that of people without asthma who were age and sex matched to the study patients. Methods We used data from the National Health Insurance Research Database. A total of 12 771 patients with newly diagnosed asthma between 2001 and 2003 were evaluated and 51 084 people without asthma were used as the comparison cohort. Cox proportional hazard regression analysis was used to measure the HR of dementia for the asthmatic cohort, compared with that of the non-asthmatic cohort. Results The HR of dementia was 1.27 (95% confidence interval (CI) 1.15 to 1.41) for the asthmatic cohort, compared with the non-asthmatic cohort after adjusting for age, sex, comorbidities, annual outpatient department visits and medicine used. The HR of dementia development increased substantially as frequency of asthma exacerbation and hospitalisation increased. Conclusions This nationwide cohort study suggests that the risk of dementia development is significantly increased in patients with asthma compared with that of the general population. In addition, dementia risk increases substantially with asthma exacerbation and hospitalisation frequency increases.</description><identifier>ISSN: 0143-005X</identifier><identifier>EISSN: 1470-2738</identifier><identifier>DOI: 10.1136/jech-2014-204445</identifier><identifier>PMID: 25271249</identifier><identifier>CODEN: JECHDR</identifier><language>eng</language><publisher>England: BMJ Publishing Group</publisher><subject>Adult ; Age ; Aged ; Asthma ; Asthma - epidemiology ; Case-Control Studies ; Chi-Square Distribution ; Cognition & reasoning ; Comorbidity ; Craniocerebral Trauma - epidemiology ; Dementia ; Dementia - epidemiology ; Dementia disorders ; Diabetes ; Female ; Head injuries ; Health insurance ; Health risk assessment ; Heart failure ; Hospitals ; Humans ; Hypertension ; Incidence ; Male ; Mens health ; Middle Aged ; Other topics ; Population ; Proportional Hazards Models ; Regression analysis ; Retrospective Studies ; Risk Factors ; Stroke ; Stroke - epidemiology ; Studies ; Taiwan - epidemiology ; Womens health ; Young Adult</subject><ispartof>Journal of epidemiology and community health (1979), 2015-02, Vol.69 (2), p.123-128</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2014 BMJ Publishing Group</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b418t-dab36ecdb4da11c073219e8e360ae9a185f40fb432e2c607941adec685e677863</citedby><cites>FETCH-LOGICAL-b418t-dab36ecdb4da11c073219e8e360ae9a185f40fb432e2c607941adec685e677863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jech.bmj.com/content/69/2/123.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jech.bmj.com/content/69/2/123.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,799,3182,23551,27903,27904,57995,58228,77346,77377</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25271249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Yi-Hao</creatorcontrib><creatorcontrib>Wu, Biing-Ru</creatorcontrib><creatorcontrib>Su, Ching-Hua</creatorcontrib><creatorcontrib>Liao, Wei-Chih</creatorcontrib><creatorcontrib>Muo, Chih-Hsin</creatorcontrib><creatorcontrib>Hsia, Te-Chun</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><title>Adult asthma increases dementia risk: a nationwide cohort study</title><title>Journal of epidemiology and community health (1979)</title><addtitle>J Epidemiol Community Health</addtitle><description>Background Studies on the association between adult asthma and dementia are few. We investigated the risk of dementia in patients diagnosed with adult asthma compared with that of people without asthma who were age and sex matched to the study patients. Methods We used data from the National Health Insurance Research Database. A total of 12 771 patients with newly diagnosed asthma between 2001 and 2003 were evaluated and 51 084 people without asthma were used as the comparison cohort. Cox proportional hazard regression analysis was used to measure the HR of dementia for the asthmatic cohort, compared with that of the non-asthmatic cohort. Results The HR of dementia was 1.27 (95% confidence interval (CI) 1.15 to 1.41) for the asthmatic cohort, compared with the non-asthmatic cohort after adjusting for age, sex, comorbidities, annual outpatient department visits and medicine used. The HR of dementia development increased substantially as frequency of asthma exacerbation and hospitalisation increased. Conclusions This nationwide cohort study suggests that the risk of dementia development is significantly increased in patients with asthma compared with that of the general population. In addition, dementia risk increases substantially with asthma exacerbation and hospitalisation frequency increases.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Cognition & reasoning</subject><subject>Comorbidity</subject><subject>Craniocerebral Trauma - epidemiology</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia disorders</subject><subject>Diabetes</subject><subject>Female</subject><subject>Head injuries</subject><subject>Health insurance</subject><subject>Health risk assessment</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Male</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Other topics</subject><subject>Population</subject><subject>Proportional Hazards Models</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - epidemiology</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0143-005X</issn><issn>1470-2738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1r2zAYxkXZWNNu9102DLsUiju9sqyPXkoIbVco9NLBbkKW3hB7sZ1JMiX__Zy4zaGXXCTB83s_9DyEfAV6BVCInw26Vc4o8PHgnJcnZAZc0pzJQn0gs1EockrLP6fkLMaGjk_J9CdyykomgXE9IzdzP6xTZmNatTarOxfQRoyZxxa7VNss1PHvdWazzqa6715qj5nrV31IWUyD334mH5d2HfHL631Oft_dPi9-5Y9P9w-L-WNecVAp97YqBDpfcW8BHJUFA40KC0EtaguqXHK6rHjBkDlBpeZgPTqhShRSKlGck4up7yb0_waMybR1dLhe2w77IRpQVAmttYLjqCgZpwB79Mc7tOmH0I0fMSClZqpUSo4UnSgX-hgDLs0m1K0NWwPU7HIwuxzMLgcz5TCWfH9tPFQt-kPBm_Ej8G0Cmpj6cNBHAxSo_WaXk161zfFx_wE2LJj7</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Peng, Yi-Hao</creator><creator>Wu, Biing-Ru</creator><creator>Su, Ching-Hua</creator><creator>Liao, Wei-Chih</creator><creator>Muo, Chih-Hsin</creator><creator>Hsia, Te-Chun</creator><creator>Kao, Chia-Hung</creator><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20150201</creationdate><title>Adult asthma increases dementia risk: a nationwide cohort study</title><author>Peng, Yi-Hao ; Wu, Biing-Ru ; Su, Ching-Hua ; Liao, Wei-Chih ; Muo, Chih-Hsin ; Hsia, Te-Chun ; Kao, Chia-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b418t-dab36ecdb4da11c073219e8e360ae9a185f40fb432e2c607941adec685e677863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Cognition & reasoning</topic><topic>Comorbidity</topic><topic>Craniocerebral Trauma - epidemiology</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia disorders</topic><topic>Diabetes</topic><topic>Female</topic><topic>Head injuries</topic><topic>Health insurance</topic><topic>Health risk assessment</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Male</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Other topics</topic><topic>Population</topic><topic>Proportional Hazards Models</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - epidemiology</topic><topic>Studies</topic><topic>Taiwan - epidemiology</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Yi-Hao</creatorcontrib><creatorcontrib>Wu, Biing-Ru</creatorcontrib><creatorcontrib>Su, Ching-Hua</creatorcontrib><creatorcontrib>Liao, Wei-Chih</creatorcontrib><creatorcontrib>Muo, Chih-Hsin</creatorcontrib><creatorcontrib>Hsia, Te-Chun</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of epidemiology and community health (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Yi-Hao</au><au>Wu, Biing-Ru</au><au>Su, Ching-Hua</au><au>Liao, Wei-Chih</au><au>Muo, Chih-Hsin</au><au>Hsia, Te-Chun</au><au>Kao, Chia-Hung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult asthma increases dementia risk: a nationwide cohort study</atitle><jtitle>Journal of epidemiology and community health (1979)</jtitle><addtitle>J Epidemiol Community Health</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>69</volume><issue>2</issue><spage>123</spage><epage>128</epage><pages>123-128</pages><issn>0143-005X</issn><eissn>1470-2738</eissn><coden>JECHDR</coden><abstract>Background Studies on the association between adult asthma and dementia are few. We investigated the risk of dementia in patients diagnosed with adult asthma compared with that of people without asthma who were age and sex matched to the study patients. Methods We used data from the National Health Insurance Research Database. A total of 12 771 patients with newly diagnosed asthma between 2001 and 2003 were evaluated and 51 084 people without asthma were used as the comparison cohort. Cox proportional hazard regression analysis was used to measure the HR of dementia for the asthmatic cohort, compared with that of the non-asthmatic cohort. Results The HR of dementia was 1.27 (95% confidence interval (CI) 1.15 to 1.41) for the asthmatic cohort, compared with the non-asthmatic cohort after adjusting for age, sex, comorbidities, annual outpatient department visits and medicine used. The HR of dementia development increased substantially as frequency of asthma exacerbation and hospitalisation increased. Conclusions This nationwide cohort study suggests that the risk of dementia development is significantly increased in patients with asthma compared with that of the general population. In addition, dementia risk increases substantially with asthma exacerbation and hospitalisation frequency increases.</abstract><cop>England</cop><pub>BMJ Publishing Group</pub><pmid>25271249</pmid><doi>10.1136/jech-2014-204445</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Aged Asthma Asthma - epidemiology Case-Control Studies Chi-Square Distribution Cognition & reasoning Comorbidity Craniocerebral Trauma - epidemiology Dementia Dementia - epidemiology Dementia disorders Diabetes Female Head injuries Health insurance Health risk assessment Heart failure Hospitals Humans Hypertension Incidence Male Mens health Middle Aged Other topics Population Proportional Hazards Models Regression analysis Retrospective Studies Risk Factors Stroke Stroke - epidemiology Studies Taiwan - epidemiology Womens health Young Adult |
| title | Adult asthma increases dementia risk: a nationwide cohort study |
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