Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes

[Display omitted] A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represented by 1, that were identified fr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-06, Vol.26 (12), p.2947-2951
Hauptverfasser:	Wilson, Jonathan E., Kurukulasuriya, Ravi, Sinz, Christopher, Lombardo, Matthew, Bender, Kate, Parker, Dann, Sherer, Edward C., Costa, Melissa, Dingley, Karen, Li, Xiaofang, Mitelman, Stanley, Tong, Sharon, Bugianesi, Randal, Ehrhardt, Anka, Priest, Birgit, Ratliff, Kevin, Ujjainwalla, Feroze, Nargund, Ravi, Hagmann, William K., Edmondson, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Diabetes Mellitus, Experimental - drug therapy Dose-Response Relationship, Drug Drug Discovery Glucose Tolerance Test GPR142 Mice Mice, Knockout Molecular Structure Oxazepines - chemical synthesis Oxazepines - chemistry Oxazepines - pharmacology Rats Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - deficiency Structure-Activity Relationship Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology Wild-type knock-out study
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!