60 YEARS OF POMC: POMC: an evolutionary perspective
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orp...
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| Veröffentlicht in: | Journal of molecular endocrinology 2016-05, Vol.56 (4), p.T113-T118 |
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| container_issue | 4 |
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| container_title | Journal of molecular endocrinology |
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| creator | Navarro, Sandra Soletto, Lucia Puchol, Sara Rotllant, Josep Soengas, Jose Luis Cerdá-Reverter, Jose Miguel |
| description | Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution. |
| doi_str_mv | 10.1530/JME-15-0288 |
| format | Article |
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POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.</description><identifier>ISSN: 0952-5041</identifier><identifier>EISSN: 1479-6813</identifier><identifier>DOI: 10.1530/JME-15-0288</identifier><identifier>PMID: 26671895</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Animals ; Biological Evolution ; Evolution, Molecular ; Gene Expression Regulation ; Humans ; Multigene Family ; Organ Specificity ; Peptide Hormones - chemistry ; Peptide Hormones - metabolism ; Pro-Opiomelanocortin - chemistry ; Pro-Opiomelanocortin - genetics ; Pro-Opiomelanocortin - metabolism ; Protein Processing, Post-Translational ; Proteolysis ; Thematic Review</subject><ispartof>Journal of molecular endocrinology, 2016-05, Vol.56 (4), p.T113-T118</ispartof><rights>2016 Society for Endocrinology</rights><rights>2016 Society for Endocrinology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b373t-ec9f51557a112e7e18afd5d9e3a5191e327c06582b8465f836a421004cdffea83</citedby><cites>FETCH-LOGICAL-b373t-ec9f51557a112e7e18afd5d9e3a5191e327c06582b8465f836a421004cdffea83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3936,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26671895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Navarro, Sandra</creatorcontrib><creatorcontrib>Soletto, Lucia</creatorcontrib><creatorcontrib>Puchol, Sara</creatorcontrib><creatorcontrib>Rotllant, Josep</creatorcontrib><creatorcontrib>Soengas, Jose Luis</creatorcontrib><creatorcontrib>Cerdá-Reverter, Jose Miguel</creatorcontrib><title>60 YEARS OF POMC: POMC: an evolutionary perspective</title><title>Journal of molecular endocrinology</title><addtitle>J Mol Endocrinol</addtitle><description>Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.</description><subject>Animals</subject><subject>Biological Evolution</subject><subject>Evolution, Molecular</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Multigene Family</subject><subject>Organ Specificity</subject><subject>Peptide Hormones - chemistry</subject><subject>Peptide Hormones - metabolism</subject><subject>Pro-Opiomelanocortin - chemistry</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Pro-Opiomelanocortin - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>Proteolysis</subject><subject>Thematic Review</subject><issn>0952-5041</issn><issn>1479-6813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AQgBdRbK2evEuOgkR3drMvb6W0Pmip-Dh4CpvNLETSpGaTgv_elFaPepmZw8cH8xFyDvQaBKc3j4tpDCKmTOsDMoREmVhq4IdkSI1gsaAJDMhJCB-UggCVHJMBk1KBNmJIuKTR-3T8_BItZ9HTcjG53U9bRbipy64t6so2X9Eam7BG1xYbPCVH3pYBz_Z7RN5m09fJfTxf3j1MxvM444q3MTrjBQihLABDhaCtz0VukFsBBpAz5agUmmU6kcJrLm3CgNLE5d6j1XxELnfedVN_dhjadFUEh2VpK6y7kIKmWhrDhfwfVUZoyZVgPXq1Q11Th9CgT9dNsepfTIGm26BpH7Q_0m3Qnr7Yi7tshfkv-1OwB2AHZEUdXIFVW_jC2T-l34oIfGU</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Navarro, Sandra</creator><creator>Soletto, Lucia</creator><creator>Puchol, Sara</creator><creator>Rotllant, Josep</creator><creator>Soengas, Jose Luis</creator><creator>Cerdá-Reverter, Jose Miguel</creator><general>Bioscientifica Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201605</creationdate><title>60 YEARS OF POMC: POMC: an evolutionary perspective</title><author>Navarro, Sandra ; Soletto, Lucia ; Puchol, Sara ; Rotllant, Josep ; Soengas, Jose Luis ; Cerdá-Reverter, Jose Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b373t-ec9f51557a112e7e18afd5d9e3a5191e327c06582b8465f836a421004cdffea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biological Evolution</topic><topic>Evolution, Molecular</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Multigene Family</topic><topic>Organ Specificity</topic><topic>Peptide Hormones - chemistry</topic><topic>Peptide Hormones - metabolism</topic><topic>Pro-Opiomelanocortin - chemistry</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Pro-Opiomelanocortin - metabolism</topic><topic>Protein Processing, Post-Translational</topic><topic>Proteolysis</topic><topic>Thematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navarro, Sandra</creatorcontrib><creatorcontrib>Soletto, Lucia</creatorcontrib><creatorcontrib>Puchol, Sara</creatorcontrib><creatorcontrib>Rotllant, Josep</creatorcontrib><creatorcontrib>Soengas, Jose Luis</creatorcontrib><creatorcontrib>Cerdá-Reverter, Jose Miguel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of molecular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navarro, Sandra</au><au>Soletto, Lucia</au><au>Puchol, Sara</au><au>Rotllant, Josep</au><au>Soengas, Jose Luis</au><au>Cerdá-Reverter, Jose Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>60 YEARS OF POMC: POMC: an evolutionary perspective</atitle><jtitle>Journal of molecular endocrinology</jtitle><addtitle>J Mol Endocrinol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>56</volume><issue>4</issue><spage>T113</spage><epage>T118</epage><pages>T113-T118</pages><issn>0952-5041</issn><eissn>1479-6813</eissn><abstract>Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>26671895</pmid><doi>10.1530/JME-15-0288</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological Evolution Evolution, Molecular Gene Expression Regulation Humans Multigene Family Organ Specificity Peptide Hormones - chemistry Peptide Hormones - metabolism Pro-Opiomelanocortin - chemistry Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Protein Processing, Post-Translational Proteolysis Thematic Review |
| title | 60 YEARS OF POMC: POMC: an evolutionary perspective |
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