Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish

•PFOS chronic exposure induces sex-dependent hepatic steotosis in zebrafish.•PFOS interferes with β-oxidation, lipid synthesis, and lipid hepatic export process.•Zebrafish could be used as an alternative model for PFOS chronic toxicity screening. Perfluorooctane sulfonate (PFOS), one persistent orga...

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Veröffentlicht in:	Aquatic toxicology 2016-07, Vol.176, p.45-52
Hauptverfasser:	Cheng, Jiangfei, Lv, Suping, Nie, Shangfei, Liu, Jing, Tong, Shoufang, Kang, Ning, Xiao, Yanyan, Dong, Qiaoxiang, Huang, Changjiang, Yang, Dongren
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - toxicity Animals Chronic exposure Danio rerio Fatty Acids - chemistry Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - veterinary Fluorocarbons - toxicity Freshwater Lipid metabolism Lipid Metabolism - drug effects Lipoproteins, HDL - blood Lipoproteins, LDL - blood Liver - chemistry Liver - metabolism Liver - pathology Male PFOS Real-Time Polymerase Chain Reaction Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - growth & development Zebrafish - metabolism
Online-Zugang:	Volltext
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