Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels
We thank Drs Quanjer and Miller for their commentaries to our recently published manuscript in the European Respiratory Journal [1]. Our manuscript describes a follow-up study of pulmonary function tests (PFTs) in two groups of healthy smokers with normal post-bronchodilator spirometry and total lun...
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| Veröffentlicht in: | The European respiratory journal 2016-06, Vol.47 (6), p.1888-1889 |
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| creator | Harvey, Ben-Gary Strulovici-Barel, Yael Kaner, Robert J Sanders, Abraham Vincent, Thomas L Mezey, Jason G Crystal, Ronald G |
| description | We thank Drs Quanjer and Miller for their commentaries to our recently published manuscript in the European Respiratory Journal [1]. Our manuscript describes a follow-up study of pulmonary function tests (PFTs) in two groups of healthy smokers with normal post-bronchodilator spirometry and total lung capacity (forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and total lung capacity (TLC) greater than or equal to 80% predicted and FEV1/FVC >0.7, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative) [2-5]. The smokers in one group had normal spirometry and normal diffusion capacity of the lung for CO (DLCO) defined as greater than or equal to 80% pred ("normal spirometry/normal DLCO", n=59) and the smokers in the other group had normal spirometry but low DLCO ( |
| doi_str_mv | 10.1183/13993003.00435-2016 |
| format | Article |
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Our manuscript describes a follow-up study of pulmonary function tests (PFTs) in two groups of healthy smokers with normal post-bronchodilator spirometry and total lung capacity (forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and total lung capacity (TLC) greater than or equal to 80% predicted and FEV1/FVC >0.7, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative) [2-5]. The smokers in one group had normal spirometry and normal diffusion capacity of the lung for CO (DLCO) defined as greater than or equal to 80% pred ("normal spirometry/normal DLCO", n=59) and the smokers in the other group had normal spirometry but low DLCO (<80% pred, "normal spirometry/low DLCO", n=46). The groups were similar in age, sex and ethnicity, with no difference in exposure to risk factors (i.e., smoking history, pack-year history, packs per day or age of smoking initiation), cough or sputum scores or emphysema score. At the end of the follow-up period (<4years, on average, for both groups), 2 (3%) out of 59 of the normal spirometry/normal DLCO smokers developed GOLD-defined COPD (FEV1/FVC <0.7) versus 10 (22%) out of 46 of the normal spirometry/low DLCO smokers (p<0.009). We concluded that despite appearing "normal" by GOLD, smokers with normal spirometry but low DLCO are at significantly higher risk for developing COPD with obstruction to airflow.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.00435-2016</identifier><identifier>PMID: 27246083</identifier><language>eng</language><publisher>England</publisher><ispartof>The European respiratory journal, 2016-06, Vol.47 (6), p.1888-1889</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27246083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harvey, Ben-Gary</creatorcontrib><creatorcontrib>Strulovici-Barel, Yael</creatorcontrib><creatorcontrib>Kaner, Robert J</creatorcontrib><creatorcontrib>Sanders, Abraham</creatorcontrib><creatorcontrib>Vincent, Thomas L</creatorcontrib><creatorcontrib>Mezey, Jason G</creatorcontrib><creatorcontrib>Crystal, Ronald G</creatorcontrib><title>Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>We thank Drs Quanjer and Miller for their commentaries to our recently published manuscript in the European Respiratory Journal [1]. Our manuscript describes a follow-up study of pulmonary function tests (PFTs) in two groups of healthy smokers with normal post-bronchodilator spirometry and total lung capacity (forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and total lung capacity (TLC) greater than or equal to 80% predicted and FEV1/FVC >0.7, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative) [2-5]. The smokers in one group had normal spirometry and normal diffusion capacity of the lung for CO (DLCO) defined as greater than or equal to 80% pred ("normal spirometry/normal DLCO", n=59) and the smokers in the other group had normal spirometry but low DLCO (<80% pred, "normal spirometry/low DLCO", n=46). The groups were similar in age, sex and ethnicity, with no difference in exposure to risk factors (i.e., smoking history, pack-year history, packs per day or age of smoking initiation), cough or sputum scores or emphysema score. At the end of the follow-up period (<4years, on average, for both groups), 2 (3%) out of 59 of the normal spirometry/normal DLCO smokers developed GOLD-defined COPD (FEV1/FVC <0.7) versus 10 (22%) out of 46 of the normal spirometry/low DLCO smokers (p<0.009). We concluded that despite appearing "normal" by GOLD, smokers with normal spirometry but low DLCO are at significantly higher risk for developing COPD with obstruction to airflow.</description><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkEtvwjAQhK2qVaG0v6BS5WMvAdvrPHysQl8SEhzaMzJ4A26TONhJEf--RIVzTyvNfjPSDCH3nI05z2DCQSlgDMaMSYgjwXhyQYa9GvXyJRkyxSDiCpIBuQnhix0JCfyaDEQqZMIyGJLdwruNxxCsq2nraD5fTKmtaajcN_pA97bd0tr5Spc0NNa7Clt_mJRuT6ezfE67YOsNNbYo0GPd0uN760zoowy26Ctb49lf4g-W4ZZcFboMeHe6I_L58vyRv0Wz-et7_jSLGg4yiZSJ40IzodfHYkbJGJJYo5ZphsWKo-RiZQpIi1XKRGGUwDQBs06ExDUILRWMyONfbuPdrsPQLisb1liWukbXhSXPWJYoxaT8H00VxEc269GHE9qtKjTLxttK-8PyvCj8Av5QeVw</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Harvey, Ben-Gary</creator><creator>Strulovici-Barel, Yael</creator><creator>Kaner, Robert J</creator><creator>Sanders, Abraham</creator><creator>Vincent, Thomas L</creator><creator>Mezey, Jason G</creator><creator>Crystal, Ronald G</creator><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201606</creationdate><title>Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels</title><author>Harvey, Ben-Gary ; Strulovici-Barel, Yael ; Kaner, Robert J ; Sanders, Abraham ; Vincent, Thomas L ; Mezey, Jason G ; Crystal, Ronald G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1346-9d55fa02ac201d945365aea478efb1e412bdf37fb702fd92e763dc624ec32a493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harvey, Ben-Gary</creatorcontrib><creatorcontrib>Strulovici-Barel, Yael</creatorcontrib><creatorcontrib>Kaner, Robert J</creatorcontrib><creatorcontrib>Sanders, Abraham</creatorcontrib><creatorcontrib>Vincent, Thomas L</creatorcontrib><creatorcontrib>Mezey, Jason G</creatorcontrib><creatorcontrib>Crystal, Ronald G</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harvey, Ben-Gary</au><au>Strulovici-Barel, Yael</au><au>Kaner, Robert J</au><au>Sanders, Abraham</au><au>Vincent, Thomas L</au><au>Mezey, Jason G</au><au>Crystal, Ronald G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2016-06</date><risdate>2016</risdate><volume>47</volume><issue>6</issue><spage>1888</spage><epage>1889</epage><pages>1888-1889</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>We thank Drs Quanjer and Miller for their commentaries to our recently published manuscript in the European Respiratory Journal [1]. Our manuscript describes a follow-up study of pulmonary function tests (PFTs) in two groups of healthy smokers with normal post-bronchodilator spirometry and total lung capacity (forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and total lung capacity (TLC) greater than or equal to 80% predicted and FEV1/FVC >0.7, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative) [2-5]. The smokers in one group had normal spirometry and normal diffusion capacity of the lung for CO (DLCO) defined as greater than or equal to 80% pred ("normal spirometry/normal DLCO", n=59) and the smokers in the other group had normal spirometry but low DLCO (<80% pred, "normal spirometry/low DLCO", n=46). The groups were similar in age, sex and ethnicity, with no difference in exposure to risk factors (i.e., smoking history, pack-year history, packs per day or age of smoking initiation), cough or sputum scores or emphysema score. At the end of the follow-up period (<4years, on average, for both groups), 2 (3%) out of 59 of the normal spirometry/normal DLCO smokers developed GOLD-defined COPD (FEV1/FVC <0.7) versus 10 (22%) out of 46 of the normal spirometry/low DLCO smokers (p<0.009). We concluded that despite appearing "normal" by GOLD, smokers with normal spirometry but low DLCO are at significantly higher risk for developing COPD with obstruction to airflow.</abstract><cop>England</cop><pmid>27246083</pmid><doi>10.1183/13993003.00435-2016</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| title | Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels |
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