MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP

Intracranial meningiomas are rare in children. We report on a 5 year-old girl who was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Va.), 2014-11, Vol.16 (suppl 5), p.v129-v129
Hauptverfasser: Juratli, T., Geiger, K., Lautenschlaeger, T., Hagen, M. V. d., Schackert, G., Kirsch, M.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page v129
container_issue suppl 5
container_start_page v129
container_title Neuro-oncology (Charlottesville, Va.)
container_volume 16
creator Juratli, T.
Geiger, K.
Lautenschlaeger, T.
Hagen, M. V. d.
Schackert, G.
Kirsch, M.
description Intracranial meningiomas are rare in children. We report on a 5 year-old girl who was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operative approach was chosen and a complete removal of the tumor was achieved. Due to recurrent tumor progressions, the child underwent several surgeries and two cranial radiations. None of the treatments were efficient enough to stop tumor progression. Consequently, the child died at the age of 14 after further extensive intra- and extracranial tumor progression. The initial histological examinations (at the age of 5 years) revealed a clear cell meningioma WHO grade II with an MIB-1 labeling index
doi_str_mv 10.1093/neuonc/nou260.10
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808698388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808698388</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1160-c884ac5a41f1d971120919fd20bde8e8ec1a476af6f70bbd87e3be1bb2e1d9b33</originalsourceid><addsrcrecordid>eNotkM1rg0AQxZfSQtO09x732Ms2OxrX9SjG6MLqhmhSehI_VkhJNNV66K1_ek0MAzPD4zdv4CH0CvQdqGMuGj20Tblo2sFgF-kOzcAyTGJxxu6vu0G4BfYjeur7L0oNsBjM0F-UEADsSd_dYs-XEm_8dKuIJ8XelTjyYxEHQkUuFjF28Vrsffx5YZVcYS8UYyc4FEmqNm4aKqkC4Y13K-EGsUpEgt14haWKA5L622j8I-IrsFZSqg-y2zyjhzo_9vrlNudot_ZTLyQ3K1ICMEpKzpd5aeVLqKFybACDOuDUlUGLSvOxSsiXNstrVtu0KCpua7PQUBSGHvnCNOfobfI9d-33oPuf7HToS3085o1uhz4DTjlzuMn5iNIJLbu27ztdZ-fucMq73wxodgk7m8LOprBHyfwHizZqVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1808698388</pqid></control><display><type>article</type><title>MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Juratli, T. ; Geiger, K. ; Lautenschlaeger, T. ; Hagen, M. V. d. ; Schackert, G. ; Kirsch, M.</creator><creatorcontrib>Juratli, T. ; Geiger, K. ; Lautenschlaeger, T. ; Hagen, M. V. d. ; Schackert, G. ; Kirsch, M.</creatorcontrib><description>Intracranial meningiomas are rare in children. We report on a 5 year-old girl who was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operative approach was chosen and a complete removal of the tumor was achieved. Due to recurrent tumor progressions, the child underwent several surgeries and two cranial radiations. None of the treatments were efficient enough to stop tumor progression. Consequently, the child died at the age of 14 after further extensive intra- and extracranial tumor progression. The initial histological examinations (at the age of 5 years) revealed a clear cell meningioma WHO grade II with an MIB-1 labeling index &lt;1%, which gradually increased with every recurrence up to 10% by the last progression at the age of 13. Analogically, an increasing over-expression of EGF-, PDGF-, and VEGF-receptors with each recurrence was observed. In reviewing the literature, there have been only 10 reported cases of intracranial clear cell meningioma in children, none of which obtained a serial pathological investigation. The pathologic findings, treatment options, and present understanding of this tumor are discussed in this work.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/nou260.10</identifier><language>eng</language><ispartof>Neuro-oncology (Charlottesville, Va.), 2014-11, Vol.16 (suppl 5), p.v129-v129</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Juratli, T.</creatorcontrib><creatorcontrib>Geiger, K.</creatorcontrib><creatorcontrib>Lautenschlaeger, T.</creatorcontrib><creatorcontrib>Hagen, M. V. d.</creatorcontrib><creatorcontrib>Schackert, G.</creatorcontrib><creatorcontrib>Kirsch, M.</creatorcontrib><title>MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>Intracranial meningiomas are rare in children. We report on a 5 year-old girl who was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operative approach was chosen and a complete removal of the tumor was achieved. Due to recurrent tumor progressions, the child underwent several surgeries and two cranial radiations. None of the treatments were efficient enough to stop tumor progression. Consequently, the child died at the age of 14 after further extensive intra- and extracranial tumor progression. The initial histological examinations (at the age of 5 years) revealed a clear cell meningioma WHO grade II with an MIB-1 labeling index &lt;1%, which gradually increased with every recurrence up to 10% by the last progression at the age of 13. Analogically, an increasing over-expression of EGF-, PDGF-, and VEGF-receptors with each recurrence was observed. In reviewing the literature, there have been only 10 reported cases of intracranial clear cell meningioma in children, none of which obtained a serial pathological investigation. The pathologic findings, treatment options, and present understanding of this tumor are discussed in this work.</description><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNotkM1rg0AQxZfSQtO09x732Ms2OxrX9SjG6MLqhmhSehI_VkhJNNV66K1_ek0MAzPD4zdv4CH0CvQdqGMuGj20Tblo2sFgF-kOzcAyTGJxxu6vu0G4BfYjeur7L0oNsBjM0F-UEADsSd_dYs-XEm_8dKuIJ8XelTjyYxEHQkUuFjF28Vrsffx5YZVcYS8UYyc4FEmqNm4aKqkC4Y13K-EGsUpEgt14haWKA5L622j8I-IrsFZSqg-y2zyjhzo_9vrlNudot_ZTLyQ3K1ICMEpKzpd5aeVLqKFybACDOuDUlUGLSvOxSsiXNstrVtu0KCpua7PQUBSGHvnCNOfobfI9d-33oPuf7HToS3085o1uhz4DTjlzuMn5iNIJLbu27ztdZ-fucMq73wxodgk7m8LOprBHyfwHizZqVg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Juratli, T.</creator><creator>Geiger, K.</creator><creator>Lautenschlaeger, T.</creator><creator>Hagen, M. V. d.</creator><creator>Schackert, G.</creator><creator>Kirsch, M.</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20141101</creationdate><title>MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP</title><author>Juratli, T. ; Geiger, K. ; Lautenschlaeger, T. ; Hagen, M. V. d. ; Schackert, G. ; Kirsch, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1160-c884ac5a41f1d971120919fd20bde8e8ec1a476af6f70bbd87e3be1bb2e1d9b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juratli, T.</creatorcontrib><creatorcontrib>Geiger, K.</creatorcontrib><creatorcontrib>Lautenschlaeger, T.</creatorcontrib><creatorcontrib>Hagen, M. V. d.</creatorcontrib><creatorcontrib>Schackert, G.</creatorcontrib><creatorcontrib>Kirsch, M.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juratli, T.</au><au>Geiger, K.</au><au>Lautenschlaeger, T.</au><au>Hagen, M. V. d.</au><au>Schackert, G.</au><au>Kirsch, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2014-11-01</date><risdate>2014</risdate><volume>16</volume><issue>suppl 5</issue><spage>v129</spage><epage>v129</epage><pages>v129-v129</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Intracranial meningiomas are rare in children. We report on a 5 year-old girl who was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operative approach was chosen and a complete removal of the tumor was achieved. Due to recurrent tumor progressions, the child underwent several surgeries and two cranial radiations. None of the treatments were efficient enough to stop tumor progression. Consequently, the child died at the age of 14 after further extensive intra- and extracranial tumor progression. The initial histological examinations (at the age of 5 years) revealed a clear cell meningioma WHO grade II with an MIB-1 labeling index &lt;1%, which gradually increased with every recurrence up to 10% by the last progression at the age of 13. Analogically, an increasing over-expression of EGF-, PDGF-, and VEGF-receptors with each recurrence was observed. In reviewing the literature, there have been only 10 reported cases of intracranial clear cell meningioma in children, none of which obtained a serial pathological investigation. The pathologic findings, treatment options, and present understanding of this tumor are discussed in this work.</abstract><doi>10.1093/neuonc/nou260.10</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1522-8517
ispartof Neuro-oncology (Charlottesville, Va.), 2014-11, Vol.16 (suppl 5), p.v129-v129
issn 1522-8517
1523-5866
language eng
recordid cdi_proquest_miscellaneous_1808698388
source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central
title MS-11 CLEAR CELL PETRO-CLIVAL MENINGIOMA IN A FIVE YEAR OLD CHILD - HISTOPATHOLOGICAL DIAGNOSIS AND LONG-TERM CLINICAL FOLLOW-UP
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T16%3A47%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MS-11%20CLEAR%20CELL%20PETRO-CLIVAL%20MENINGIOMA%20IN%20A%20FIVE%20YEAR%20OLD%20CHILD%20-%20HISTOPATHOLOGICAL%20DIAGNOSIS%20AND%20LONG-TERM%20CLINICAL%20FOLLOW-UP&rft.jtitle=Neuro-oncology%20(Charlottesville,%20Va.)&rft.au=Juratli,%20T.&rft.date=2014-11-01&rft.volume=16&rft.issue=suppl%205&rft.spage=v129&rft.epage=v129&rft.pages=v129-v129&rft.issn=1522-8517&rft.eissn=1523-5866&rft_id=info:doi/10.1093/neuonc/nou260.10&rft_dat=%3Cproquest_cross%3E1808698388%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1808698388&rft_id=info:pmid/&rfr_iscdi=true