Toll-Interleukin 1 Receptor domain-containing adaptor protein positively regulates BV2 cell M1 polarization

Microglial activation, including classical (M1) and alternative (M2) activation, plays important roles in the development of several central nervous system disorders and promotes tissue reconstruction. Toll‐like receptor (TLR)4 is important for microglial polarization. TIR domain‐containing adaptor...

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Veröffentlicht in:	The European journal of neuroscience 2016-06, Vol.43 (12), p.1674-1682
Hauptverfasser:	Gong, Leilei, Wang, Hanxiang, Sun, Xiaolei, Liu, Chun, Duan, Chengwei, Cai, Rixin, Gu, Xingxing, Zhu, Shunxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BV2 cells Cell Line Cell Polarity Encephalitis - chemically induced Encephalitis - metabolism I-kappa B Kinase - metabolism Interferon-gamma - administration & dosage Lipopolysaccharides LPS/IFN-γ M1 polarization MAP Kinase Kinase Kinases - metabolism Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Microglia - metabolism Mitogen-Activated Protein Kinases - metabolism neuroinflammation NF-kappa B - metabolism NF-κB signalling pathways Primary Cell Culture Proto-Oncogene Proteins c-akt - metabolism Receptors, Interleukin-1 - metabolism Signal Transduction TIRAP Toll-Like Receptor 4 - metabolism
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