Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation

IntroductionRadiofrequency ablation (RFA), a palliative therapeutic option for solid hepatic tumours, stimulates localised and systemic antitumour cytotoxic T cells. We studied how far addition of CpG B oligonucleotides, toll like receptor (TLR) 9 agonists, would increase the antitumoural T cell res...

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Veröffentlicht in:	Gut 2016-01, Vol.65 (1), p.134-143
Hauptverfasser:	Behm, Barbara, Di Fazio, Pietro, Michl, Patrick, Neureiter, Daniel, Kemmerling, Ralf, Hahn, Eckhart Georg, Strobel, Deike, Gress, Thomas, Schuppan, Detlef, Wissniowski, Thaddaeus Till
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antineoplastic Agents - therapeutic use Cancer therapies Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Catheter Ablation Cell Line, Tumor Chemotherapy Clinical trials Combined Modality Therapy Cytokines Cytotoxicity Drinking water Ethics Female Gangrene Immunology Liver cancer Liver Neoplasms - immunology Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - therapy Liver Neoplasms, Experimental - mortality Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - therapy Lymphocytes Melanoma Neoplasm Transplantation Oligodeoxyribonucleotides - therapeutic use Rabbits Radios Random Allocation T-Lymphocytes, Cytotoxic - metabolism Toll-Like Receptor 9 - agonists Treatment Outcome Tumor necrosis factor-TNF Tumors Vaccines
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