Galectin-3 regulates hepatic progenitor cell expansion during liver injury

Objective Following chronic liver injury or when hepatocyte proliferation is impaired, ductular reactions containing hepatic progenitor cells (HPCs) appear in the periportal regions and can regenerate the liver parenchyma. HPCs exist in a niche composed of myofibroblasts, macrophages and laminin mat...

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Veröffentlicht in:	Gut 2015-02, Vol.64 (2), p.312-321
Hauptverfasser:	Hsieh, Wei-Chen, Mackinnon, Alison C, Lu, Wei-Yu, Jung, Jonathan, Boulter, Luke, Henderson, Neil C, Simpson, Kenneth J, Schotanus, Baukje, Wojtacha, Davina, Bird, Tom G, Medine, Claire N, Hay, David C, Sethi, Tariq, Iredale, John P, Forbes, Stuart J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Cell Adhesion - physiology Cell cycle Cell Proliferation Cells, Cultured Coculture Techniques Diet - adverse effects Expansion Galectin 3 - biosynthesis Galectin 3 - deficiency Galectin 3 - physiology Hepatocytes - physiology Humans Immunoglobulins Laminin - metabolism Liver - injuries Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Liver Regeneration - physiology Macrophages - metabolism Macrophages - physiology Male Mice, Inbred C57BL Mice, Knockout Morphology Rodents Stem Cell Niche - physiology Stem Cells - metabolism Stem Cells - pathology Stem Cells - physiology Up-Regulation
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