Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the an...
Gespeichert in:
| Veröffentlicht in: | Development (Cambridge) 2016-06, Vol.143 (12), p.2206-2216 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2216 |
|---|---|
| container_issue | 12 |
| container_start_page | 2206 |
| container_title | Development (Cambridge) |
| container_volume | 143 |
| creator | Mašek, Jan Machoň, Ondřej Kořínek, Vladimír Taketo, M Mark Kozmik, Zbyněk |
| description | The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient. |
| doi_str_mv | 10.1242/dev.132357 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808693788</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1797544348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-883a03a496aac868111ee942cf4f266909eed02e6f073f8b419ca038f9145d923</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EoqWw4QOQlwgpxa_YniVCvKRKbMo6cp0xBCVNsR0k_p6UFrasZjFn7h0dQs45m3OhxHWNn3MuhSzNAZlyZUwBXMAhmTIoWcEB-IScpPTOGJPamGMyEUYyIcFMyWLpg2k53cQ-o8-J5jekbp0xNn2kaxyia2no25qG2HfU1f0mN-vXH2y_9RFTpsFlPCVHwbUJz_ZzRl7u75a3j8Xi-eHp9mZReFnqXFgrHZNOgXbOW20554ighA8qCK2BAWLNBOrAjAx2pTj48cAG4KqsQcgZudzljl9_DGN71TXJY9u6NfZDqrhlVoM0Y9G_qAFTKiXVFr3aoT72KUUM1SY2nYtfFWfVVnQ1iq52okf4Yp87rDqs_9Bfs_Ibb9d3aQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1797544348</pqid></control><display><type>article</type><title>Tcf7l1 protects the anterior neural fold from adopting the neural crest fate</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Mašek, Jan ; Machoň, Ondřej ; Kořínek, Vladimír ; Taketo, M Mark ; Kozmik, Zbyněk</creator><creatorcontrib>Mašek, Jan ; Machoň, Ondřej ; Kořínek, Vladimír ; Taketo, M Mark ; Kozmik, Zbyněk</creatorcontrib><description>The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.132357</identifier><identifier>PMID: 27302397</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; beta Catenin - metabolism ; Biomarkers - metabolism ; Cell Lineage ; Cell Transdifferentiation ; Gene Deletion ; Humans ; Integrases - metabolism ; Mice, Transgenic ; Neural Crest - cytology ; Neural Crest - metabolism ; Neural Tube Defects - metabolism ; Neural Tube Defects - pathology ; Phenotype ; Prosencephalon - embryology ; Prosencephalon - metabolism ; Repressor Proteins - metabolism ; Transcription Factor 7-Like 1 Protein - metabolism ; Transcription Factor AP-2 - metabolism ; Wnt Signaling Pathway ; Zebrafish - metabolism ; Zebrafish Proteins - metabolism</subject><ispartof>Development (Cambridge), 2016-06, Vol.143 (12), p.2206-2216</ispartof><rights>2016. Published by The Company of Biologists Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-883a03a496aac868111ee942cf4f266909eed02e6f073f8b419ca038f9145d923</citedby><cites>FETCH-LOGICAL-c356t-883a03a496aac868111ee942cf4f266909eed02e6f073f8b419ca038f9145d923</cites><orcidid>0000-0002-5139-1406</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3665,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27302397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mašek, Jan</creatorcontrib><creatorcontrib>Machoň, Ondřej</creatorcontrib><creatorcontrib>Kořínek, Vladimír</creatorcontrib><creatorcontrib>Taketo, M Mark</creatorcontrib><creatorcontrib>Kozmik, Zbyněk</creatorcontrib><title>Tcf7l1 protects the anterior neural fold from adopting the neural crest fate</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.</description><subject>Animals</subject><subject>beta Catenin - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Cell Lineage</subject><subject>Cell Transdifferentiation</subject><subject>Gene Deletion</subject><subject>Humans</subject><subject>Integrases - metabolism</subject><subject>Mice, Transgenic</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - metabolism</subject><subject>Neural Tube Defects - metabolism</subject><subject>Neural Tube Defects - pathology</subject><subject>Phenotype</subject><subject>Prosencephalon - embryology</subject><subject>Prosencephalon - metabolism</subject><subject>Repressor Proteins - metabolism</subject><subject>Transcription Factor 7-Like 1 Protein - metabolism</subject><subject>Transcription Factor AP-2 - metabolism</subject><subject>Wnt Signaling Pathway</subject><subject>Zebrafish - metabolism</subject><subject>Zebrafish Proteins - metabolism</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqWw4QOQlwgpxa_YniVCvKRKbMo6cp0xBCVNsR0k_p6UFrasZjFn7h0dQs45m3OhxHWNn3MuhSzNAZlyZUwBXMAhmTIoWcEB-IScpPTOGJPamGMyEUYyIcFMyWLpg2k53cQ-o8-J5jekbp0xNn2kaxyia2no25qG2HfU1f0mN-vXH2y_9RFTpsFlPCVHwbUJz_ZzRl7u75a3j8Xi-eHp9mZReFnqXFgrHZNOgXbOW20554ighA8qCK2BAWLNBOrAjAx2pTj48cAG4KqsQcgZudzljl9_DGN71TXJY9u6NfZDqrhlVoM0Y9G_qAFTKiXVFr3aoT72KUUM1SY2nYtfFWfVVnQ1iq52okf4Yp87rDqs_9Bfs_Ibb9d3aQ</recordid><startdate>20160615</startdate><enddate>20160615</enddate><creator>Mašek, Jan</creator><creator>Machoň, Ondřej</creator><creator>Kořínek, Vladimír</creator><creator>Taketo, M Mark</creator><creator>Kozmik, Zbyněk</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-5139-1406</orcidid></search><sort><creationdate>20160615</creationdate><title>Tcf7l1 protects the anterior neural fold from adopting the neural crest fate</title><author>Mašek, Jan ; Machoň, Ondřej ; Kořínek, Vladimír ; Taketo, M Mark ; Kozmik, Zbyněk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-883a03a496aac868111ee942cf4f266909eed02e6f073f8b419ca038f9145d923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>beta Catenin - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Cell Lineage</topic><topic>Cell Transdifferentiation</topic><topic>Gene Deletion</topic><topic>Humans</topic><topic>Integrases - metabolism</topic><topic>Mice, Transgenic</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - metabolism</topic><topic>Neural Tube Defects - metabolism</topic><topic>Neural Tube Defects - pathology</topic><topic>Phenotype</topic><topic>Prosencephalon - embryology</topic><topic>Prosencephalon - metabolism</topic><topic>Repressor Proteins - metabolism</topic><topic>Transcription Factor 7-Like 1 Protein - metabolism</topic><topic>Transcription Factor AP-2 - metabolism</topic><topic>Wnt Signaling Pathway</topic><topic>Zebrafish - metabolism</topic><topic>Zebrafish Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mašek, Jan</creatorcontrib><creatorcontrib>Machoň, Ondřej</creatorcontrib><creatorcontrib>Kořínek, Vladimír</creatorcontrib><creatorcontrib>Taketo, M Mark</creatorcontrib><creatorcontrib>Kozmik, Zbyněk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mašek, Jan</au><au>Machoň, Ondřej</au><au>Kořínek, Vladimír</au><au>Taketo, M Mark</au><au>Kozmik, Zbyněk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tcf7l1 protects the anterior neural fold from adopting the neural crest fate</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2016-06-15</date><risdate>2016</risdate><volume>143</volume><issue>12</issue><spage>2206</spage><epage>2216</epage><pages>2206-2216</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.</abstract><cop>England</cop><pmid>27302397</pmid><doi>10.1242/dev.132357</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5139-1406</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2016-06, Vol.143 (12), p.2206-2216 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808693788 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals beta Catenin - metabolism Biomarkers - metabolism Cell Lineage Cell Transdifferentiation Gene Deletion Humans Integrases - metabolism Mice, Transgenic Neural Crest - cytology Neural Crest - metabolism Neural Tube Defects - metabolism Neural Tube Defects - pathology Phenotype Prosencephalon - embryology Prosencephalon - metabolism Repressor Proteins - metabolism Transcription Factor 7-Like 1 Protein - metabolism Transcription Factor AP-2 - metabolism Wnt Signaling Pathway Zebrafish - metabolism Zebrafish Proteins - metabolism |
| title | Tcf7l1 protects the anterior neural fold from adopting the neural crest fate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T23%3A01%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tcf7l1%20protects%20the%20anterior%20neural%20fold%20from%20adopting%20the%20neural%20crest%20fate&rft.jtitle=Development%20(Cambridge)&rft.au=Ma%C5%A1ek,%20Jan&rft.date=2016-06-15&rft.volume=143&rft.issue=12&rft.spage=2206&rft.epage=2216&rft.pages=2206-2216&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.132357&rft_dat=%3Cproquest_cross%3E1797544348%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1797544348&rft_id=info:pmid/27302397&rfr_iscdi=true |