Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways

Cisplatin is widely used as a standard chemotherapy for solid tumors. The major adverse effect of cisplatin is nephrotoxicity in proximal tubular cells, via oxidative stress, DNA damage, cell apoptosis, and inflammation. The aim of this study was to investigate the pharmacological effect and mechani...

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Veröffentlicht in:	Journal of toxicological sciences 2016/06/01, Vol.41(3), pp.339-349
Hauptverfasser:	Thongnuanjan, Penjai, Soodvilai, Sirima, Chatsudthipong, Varanuj, Soodvilai, Sunhapas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Apoptosis - drug effects Cancer Cell Survival - drug effects Cisplatin Cisplatin - toxicity Cytoprotection Dose-Response Relationship, Drug Fenofibrate - pharmacology Fibrate drugs Hep G2 Cells Humans JNK activation JNK Mitogen-Activated Protein Kinases - metabolism Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Kidney Tubules, Proximal - pathology LLC-PK1 Cells Neoplasms - drug therapy Neoplasms - pathology p38 activation p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protective Agents - pharmacology Proximal tubule Signal Transduction - drug effects Swine
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