Interpreting the behavior of concentration–response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions

[Display omitted] Hyaluronan-degrading enzyme (hyaluronidase) is involved in tumor growth and inflammation, and as such, hyaluronidase inhibitors have received recent attention as potential therapeutics. The previous studies have successfully discovered a wide range of inhibitors, but unfortunately...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-07, Vol.26 (13), p.3153-3157
Hauptverfasser:	Tomohara, Keisuke, Ito, Tomohiro, Onikata, Saika, Furusawa, Kota, Kato, Atsushi, Adachi, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Chondroitin Sulfates - chemical synthesis Chondroitin Sulfates - chemistry Chondroitin Sulfates - pharmacology Concentration–response curve Cromolyn Sodium - chemical synthesis Cromolyn Sodium - chemistry Cromolyn Sodium - pharmacology Dimethyl Sulfoxide - chemistry DMSO Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Flavonoids - chemical synthesis Flavonoids - chemistry Flavonoids - pharmacology Glycyrrhizic Acid - chemical synthesis Glycyrrhizic Acid - chemistry Glycyrrhizic Acid - pharmacology Hyaluronidase inhibitor Hyaluronoglucosaminidase - antagonists & inhibitors Hyaluronoglucosaminidase - metabolism Molecular Structure Non-specific binding Perturbation Structure-Activity Relationship
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