Promotion of breast cancer cells MDA-MB-231 invasion by di(2-ethylhexyl)phthalate through matrix metalloproteinase-2/-9 overexpression

Di(2-ethylhexyl)phthalate (DEHP) is an estrogenic chemical that is widely used in polyvinyl products. We aimed to determine the mechanisms behind the effects of DEHP on ERα-negative breast cancer cells MDA-MB-231 invasion and matrix metalloproteinases-2/-9 (MMP-2/-9) up-regulation in this study. Tra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental science and pollution research international 2016-05, Vol.23 (10), p.9742-9749
Hauptverfasser:	Zhang, Shuya, Ma, Jiehua, Fu, Ziyi, Zhang, Zhilei, Cao, Jian, Huang, Lei, Li, Wenqu, Xu, Pengfei, Cao, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Breast cancer Breast Neoplasms - chemically induced Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell growth Cell Line, Tumor Chemicals Childrens health Diethylhexyl Phthalate - toxicity Earth and Environmental Science Ecotoxicology Endocrine Disruptors - toxicity Environment Environmental Chemistry Environmental Health Environmental Pollutants - toxicity Enzyme Induction - drug effects Estrogen Receptor alpha - metabolism Female Gelatinase A Gene Expression - drug effects Gene Expression Regulation, Neoplastic - drug effects Hospitals Humans Immunofluorescence Maternal & child health Matrix metalloproteinase Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Metalloproteinase Metastasis mRNA Neoplasm Invasiveness NF-kappa B - metabolism NF-κB protein Phthalates Proteins Quantitative analysis Research Article Signal Transduction - drug effects Statistical analysis Toxicity Transcription factors Translocation Up-Regulation Waste Water Technology Water Management Water Pollution Control Western blotting Xenoestrogens
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!