Impaired NK cells’ activity and increased numbers of CD4+CD25+ regulatory T cells in multidrug-resistant Mycobacterium tuberculosis patients

Abstract Multidrug-resistant tuberculosis (MDR-TB) often causes persistent infection and chemotherapy failure, which brings heavy burden of society and family. Many immune cell subsets and regulatory mechanisms may operate throughout the various stages of infection. The presence of regulatory T cell...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2016-05, Vol.98, p.13-20
Hauptverfasser:	Fan, Renhua, Xiang, Yangen, Yang, Li, Liu, Yanke, Chen, Pingsheng, Wang, Lei, Feng, Wenjun, Yin, Ke, Fu, Manjiao, Xu, Yixin, Wu, Jialin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - blood Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - blood Antigens, Differentiation, T-Lymphocyte - immunology Biomarkers - blood Case-Control Studies CD4 + CD25+ regulatory T cells CD69 Cell Communication Cell Proliferation Coculture Techniques Cytotoxicity, Immunologic Female Humans Immunity, Innate Infectious Disease Interleukin-10 - blood Interleukin-10 - immunology Interleukin-2 Receptor alpha Subunit - blood Interleukin-2 Receptor alpha Subunit - immunology K562 Cells Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - microbiology Lectins, C-Type - blood Lectins, C-Type - immunology Lymphocyte Activation Male Middle Aged Multidrug-resistant tuberculosis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity NK cells' activity Pulmonary/Respiratory T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - microbiology Tuberculosis, Multidrug-Resistant - blood Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - immunology Tuberculosis, Multidrug-Resistant - microbiology Young Adult
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