ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation

Estrogen receptor alpha (ERα) has a pivotal role in breast carcinogenesis by associating with various cellular factors. Selective expression of additional sex comb-like 2 (ASXL2) in ERα-positive breast cancer cells prompted us to investigate its role in chromatin modification required for ERα activa...

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Veröffentlicht in:	Oncogene 2016-07, Vol.35 (28), p.3742-3752
Hauptverfasser:	Park, U-H, Kang, M-R, Kim, E-J, Kwon, Y-S, Hur, W, Yoon, S K, Song, B-J, Park, J H, Hwang, J-T, Jeong, J-C, Um, S-J
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 38/61 631/337/176 631/45 64 64/60 96/95 Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis Care and treatment Cell Biology Cell Proliferation Cell size Cellular proteins Chromatin Development and progression DNA methylation DNA-Binding Proteins - metabolism Estrogen Receptor alpha - metabolism Estrogen receptors Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Health aspects HEK293 Cells Histone Demethylases - metabolism Histone H3 Histones Histones - metabolism Human Genetics Humans Immunoprecipitation Internal Medicine Lysine Lysine - metabolism MCF-7 Cells Medicine Medicine & Public Health Methylation Mice, Inbred BALB C Mice, Nude Neoplasm Proteins - metabolism Oncology original-article Prognosis Properties Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence analysis Transplantation, Heterologous Xenografts
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