Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study
ObjectiveSeveral genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (...
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| Veröffentlicht in: | Gut 2015-09, Vol.64 (9), p.1426-1433 |
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| creator | Derikx, Monique H Kovacs, Peter Scholz, Markus Masson, Emmanuelle Chen, Jian-Min Ruffert, Claudia Lichtner, Peter te Morsche, Rene H M Cavestro, Giulia Martina Férec, Claude Drenth, Joost P H Witt, Heiko Rosendahl, Jonas |
| description | ObjectiveSeveral genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large European cohort.DesignWe studied 3062 patients with alcohol-related CP (ACP) or NACP and 5107 controls. Also, 1559 German patients with alcohol-associated cirrhosis or alcohol dependence were included for comparison. We performed several meta-analyses to examine genotype–phenotype relationships.ResultsAssociation with ACP was found for rs10273639 (OR, 0.63; 95% CI 0.55 to 0.72). ACP was also associated with variants rs7057398 and rs12688220 in men (OR, 2.26; 95% CI 1.94 to 2.63 and OR, 2.66; 95% CI 2.21 to 3.21, respectively) and in women (OR, 1.57; 95% CI 1.14 to 2.18 and OR 1.71; 95% CI 1.41 to 2.07, respectively). Similar results were obtained when German patients with ACP were compared with those with alcohol-associated cirrhosis or alcohol dependence. In the overall population of patients with NACP, association with rs10273639 was absent (OR, 0.93; 95% CI 0.79 to 1.01), whereas rs7057398 of the X chromosomal single nucleotide polymorphisms was associated with NACP in women only (OR, 1.32; 95% CI 1.15 to 1.51).ConclusionsThe single-nucleotide polymorphisms rs10273639 at the PRSS1–PRSS2 locus and rs7057398 and rs12688220 at the CLDN2–MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients. |
| doi_str_mv | 10.1136/gutjnl-2014-307453 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808689555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808689555</sourcerecordid><originalsourceid>FETCH-LOGICAL-b402t-14eefe621bcfde529ada0a12cbf971010fd8ceaf134751a2a81f908e02420d803</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi1ERYfCC7BAltiwMfV17MRZomkpSNMftbC2HMdhMkrsYDtCs-MdKl6QJ8FDCkisWH3Sved-utJB6AXQNwBFefp5Tjs3EEaBk4JWXBSP0Ap4KUnBpHyMVpRCRUTF62P0NMYdpVTKGp6gYyaYKIBVK_T9xg_70Ydp28cxYp3wze3dHfz4dn9IhrVr8XpzdsXy5PL6ds3x4E2PdYw5dLL4a5-2WA_Gb_3Qm1-88478nZht8C7npJ0JVqc-9RH3Dmt8Pgc_We1wsFMm88o7HNPc7p-ho04P0T5_yBP06d35x_V7srm--LB-uyENpywR4NZ2tmTQmK61gtW61VQDM01XV0CBdq00VndQ8EqAZlpCV1NpKeOMtpIWJ-j10jsF_2W2Mamxj8YOg3bWz1GBpLKUtRAio6_-QXd-Di5_p6Cqal6KGspMsYUywccYbKem0I867BVQdZCmFmnqIE0t0vLRy4fquRlt--fkt6UMkAVoxt3_FP4Ex62lBg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779465916</pqid></control><display><type>article</type><title>Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Derikx, Monique H ; Kovacs, Peter ; Scholz, Markus ; Masson, Emmanuelle ; Chen, Jian-Min ; Ruffert, Claudia ; Lichtner, Peter ; te Morsche, Rene H M ; Cavestro, Giulia Martina ; Férec, Claude ; Drenth, Joost P H ; Witt, Heiko ; Rosendahl, Jonas</creator><creatorcontrib>Derikx, Monique H ; Kovacs, Peter ; Scholz, Markus ; Masson, Emmanuelle ; Chen, Jian-Min ; Ruffert, Claudia ; Lichtner, Peter ; te Morsche, Rene H M ; Cavestro, Giulia Martina ; Férec, Claude ; Drenth, Joost P H ; Witt, Heiko ; Rosendahl, Jonas ; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators ; PanEuropean Working group on Alcoholic Chronic Pancreatitis members and collaborators</creatorcontrib><description>ObjectiveSeveral genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large European cohort.DesignWe studied 3062 patients with alcohol-related CP (ACP) or NACP and 5107 controls. Also, 1559 German patients with alcohol-associated cirrhosis or alcohol dependence were included for comparison. We performed several meta-analyses to examine genotype–phenotype relationships.ResultsAssociation with ACP was found for rs10273639 (OR, 0.63; 95% CI 0.55 to 0.72). ACP was also associated with variants rs7057398 and rs12688220 in men (OR, 2.26; 95% CI 1.94 to 2.63 and OR, 2.66; 95% CI 2.21 to 3.21, respectively) and in women (OR, 1.57; 95% CI 1.14 to 2.18 and OR 1.71; 95% CI 1.41 to 2.07, respectively). Similar results were obtained when German patients with ACP were compared with those with alcohol-associated cirrhosis or alcohol dependence. In the overall population of patients with NACP, association with rs10273639 was absent (OR, 0.93; 95% CI 0.79 to 1.01), whereas rs7057398 of the X chromosomal single nucleotide polymorphisms was associated with NACP in women only (OR, 1.32; 95% CI 1.15 to 1.51).ConclusionsThe single-nucleotide polymorphisms rs10273639 at the PRSS1–PRSS2 locus and rs7057398 and rs12688220 at the CLDN2–MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2014-307453</identifier><identifier>PMID: 25253127</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Case-Control Studies ; Chromosomes ; Claudins - genetics ; Confidence Intervals ; Europe ; Female ; Genes ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Liver cirrhosis ; Male ; Middle Aged ; Nuclear Proteins - genetics ; Odds Ratio ; Pancreatitis, Alcoholic - genetics ; Pancreatitis, Alcoholic - mortality ; Pancreatitis, Alcoholic - physiopathology ; Pancreatitis, Chronic - genetics ; Pancreatitis, Chronic - mortality ; Pancreatitis, Chronic - physiopathology ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Reference Values ; Sex Factors ; Studies ; Survival Analysis ; Trypsin - genetics ; Trypsinogen - genetics</subject><ispartof>Gut, 2015-09, Vol.64 (9), p.1426-1433</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b402t-14eefe621bcfde529ada0a12cbf971010fd8ceaf134751a2a81f908e02420d803</citedby><cites>FETCH-LOGICAL-b402t-14eefe621bcfde529ada0a12cbf971010fd8ceaf134751a2a81f908e02420d803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://gut.bmj.com/content/64/9/1426.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://gut.bmj.com/content/64/9/1426.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25253127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Derikx, Monique H</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Masson, Emmanuelle</creatorcontrib><creatorcontrib>Chen, Jian-Min</creatorcontrib><creatorcontrib>Ruffert, Claudia</creatorcontrib><creatorcontrib>Lichtner, Peter</creatorcontrib><creatorcontrib>te Morsche, Rene H M</creatorcontrib><creatorcontrib>Cavestro, Giulia Martina</creatorcontrib><creatorcontrib>Férec, Claude</creatorcontrib><creatorcontrib>Drenth, Joost P H</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><creatorcontrib>PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators</creatorcontrib><creatorcontrib>PanEuropean Working group on Alcoholic Chronic Pancreatitis members and collaborators</creatorcontrib><title>Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study</title><title>Gut</title><addtitle>Gut</addtitle><description>ObjectiveSeveral genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large European cohort.DesignWe studied 3062 patients with alcohol-related CP (ACP) or NACP and 5107 controls. Also, 1559 German patients with alcohol-associated cirrhosis or alcohol dependence were included for comparison. We performed several meta-analyses to examine genotype–phenotype relationships.ResultsAssociation with ACP was found for rs10273639 (OR, 0.63; 95% CI 0.55 to 0.72). ACP was also associated with variants rs7057398 and rs12688220 in men (OR, 2.26; 95% CI 1.94 to 2.63 and OR, 2.66; 95% CI 2.21 to 3.21, respectively) and in women (OR, 1.57; 95% CI 1.14 to 2.18 and OR 1.71; 95% CI 1.41 to 2.07, respectively). Similar results were obtained when German patients with ACP were compared with those with alcohol-associated cirrhosis or alcohol dependence. In the overall population of patients with NACP, association with rs10273639 was absent (OR, 0.93; 95% CI 0.79 to 1.01), whereas rs7057398 of the X chromosomal single nucleotide polymorphisms was associated with NACP in women only (OR, 1.32; 95% CI 1.15 to 1.51).ConclusionsThe single-nucleotide polymorphisms rs10273639 at the PRSS1–PRSS2 locus and rs7057398 and rs12688220 at the CLDN2–MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients.</description><subject>Case-Control Studies</subject><subject>Chromosomes</subject><subject>Claudins - genetics</subject><subject>Confidence Intervals</subject><subject>Europe</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nuclear Proteins - genetics</subject><subject>Odds Ratio</subject><subject>Pancreatitis, Alcoholic - genetics</subject><subject>Pancreatitis, Alcoholic - mortality</subject><subject>Pancreatitis, Alcoholic - physiopathology</subject><subject>Pancreatitis, Chronic - genetics</subject><subject>Pancreatitis, Chronic - mortality</subject><subject>Pancreatitis, Chronic - physiopathology</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Trypsin - genetics</subject><subject>Trypsinogen - genetics</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1DAURi1ERYfCC7BAltiwMfV17MRZomkpSNMftbC2HMdhMkrsYDtCs-MdKl6QJ8FDCkisWH3Sved-utJB6AXQNwBFefp5Tjs3EEaBk4JWXBSP0Ap4KUnBpHyMVpRCRUTF62P0NMYdpVTKGp6gYyaYKIBVK_T9xg_70Ydp28cxYp3wze3dHfz4dn9IhrVr8XpzdsXy5PL6ds3x4E2PdYw5dLL4a5-2WA_Gb_3Qm1-88478nZht8C7npJ0JVqc-9RH3Dmt8Pgc_We1wsFMm88o7HNPc7p-ho04P0T5_yBP06d35x_V7srm--LB-uyENpywR4NZ2tmTQmK61gtW61VQDM01XV0CBdq00VndQ8EqAZlpCV1NpKeOMtpIWJ-j10jsF_2W2Mamxj8YOg3bWz1GBpLKUtRAio6_-QXd-Di5_p6Cqal6KGspMsYUywccYbKem0I867BVQdZCmFmnqIE0t0vLRy4fquRlt--fkt6UMkAVoxt3_FP4Ex62lBg</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Derikx, Monique H</creator><creator>Kovacs, Peter</creator><creator>Scholz, Markus</creator><creator>Masson, Emmanuelle</creator><creator>Chen, 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and non-alcoholic chronic pancreatitis in a European replication study</title><author>Derikx, Monique H ; Kovacs, Peter ; Scholz, Markus ; Masson, Emmanuelle ; Chen, Jian-Min ; Ruffert, Claudia ; Lichtner, Peter ; te Morsche, Rene H M ; Cavestro, Giulia Martina ; Férec, Claude ; Drenth, Joost P H ; Witt, Heiko ; Rosendahl, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b402t-14eefe621bcfde529ada0a12cbf971010fd8ceaf134751a2a81f908e02420d803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Case-Control Studies</topic><topic>Chromosomes</topic><topic>Claudins - genetics</topic><topic>Confidence Intervals</topic><topic>Europe</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nuclear Proteins - genetics</topic><topic>Odds Ratio</topic><topic>Pancreatitis, Alcoholic - genetics</topic><topic>Pancreatitis, Alcoholic - mortality</topic><topic>Pancreatitis, Alcoholic - physiopathology</topic><topic>Pancreatitis, Chronic - genetics</topic><topic>Pancreatitis, Chronic - mortality</topic><topic>Pancreatitis, Chronic - physiopathology</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Studies</topic><topic>Survival Analysis</topic><topic>Trypsin - genetics</topic><topic>Trypsinogen - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derikx, Monique H</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Masson, Emmanuelle</creatorcontrib><creatorcontrib>Chen, Jian-Min</creatorcontrib><creatorcontrib>Ruffert, Claudia</creatorcontrib><creatorcontrib>Lichtner, Peter</creatorcontrib><creatorcontrib>te Morsche, Rene H M</creatorcontrib><creatorcontrib>Cavestro, Giulia Martina</creatorcontrib><creatorcontrib>Férec, Claude</creatorcontrib><creatorcontrib>Drenth, Joost P H</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><creatorcontrib>PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators</creatorcontrib><creatorcontrib>PanEuropean Working group on Alcoholic Chronic Pancreatitis members and collaborators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical 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Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Derikx, Monique H</au><au>Kovacs, Peter</au><au>Scholz, Markus</au><au>Masson, Emmanuelle</au><au>Chen, Jian-Min</au><au>Ruffert, Claudia</au><au>Lichtner, Peter</au><au>te Morsche, Rene H M</au><au>Cavestro, Giulia Martina</au><au>Férec, Claude</au><au>Drenth, Joost P H</au><au>Witt, Heiko</au><au>Rosendahl, Jonas</au><aucorp>PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators</aucorp><aucorp>PanEuropean Working group on Alcoholic Chronic Pancreatitis members and collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>64</volume><issue>9</issue><spage>1426</spage><epage>1433</epage><pages>1426-1433</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>ObjectiveSeveral genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large European cohort.DesignWe studied 3062 patients with alcohol-related CP (ACP) or NACP and 5107 controls. Also, 1559 German patients with alcohol-associated cirrhosis or alcohol dependence were included for comparison. We performed several meta-analyses to examine genotype–phenotype relationships.ResultsAssociation with ACP was found for rs10273639 (OR, 0.63; 95% CI 0.55 to 0.72). ACP was also associated with variants rs7057398 and rs12688220 in men (OR, 2.26; 95% CI 1.94 to 2.63 and OR, 2.66; 95% CI 2.21 to 3.21, respectively) and in women (OR, 1.57; 95% CI 1.14 to 2.18 and OR 1.71; 95% CI 1.41 to 2.07, respectively). Similar results were obtained when German patients with ACP were compared with those with alcohol-associated cirrhosis or alcohol dependence. In the overall population of patients with NACP, association with rs10273639 was absent (OR, 0.93; 95% CI 0.79 to 1.01), whereas rs7057398 of the X chromosomal single nucleotide polymorphisms was associated with NACP in women only (OR, 1.32; 95% CI 1.15 to 1.51).ConclusionsThe single-nucleotide polymorphisms rs10273639 at the PRSS1–PRSS2 locus and rs7057398 and rs12688220 at the CLDN2–MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25253127</pmid><doi>10.1136/gutjnl-2014-307453</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut, 2015-09, Vol.64 (9), p.1426-1433 |
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| source | MEDLINE; BMJ Journals - NESLi2; PubMed Central |
| subjects | Case-Control Studies Chromosomes Claudins - genetics Confidence Intervals Europe Female Genes Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Liver cirrhosis Male Middle Aged Nuclear Proteins - genetics Odds Ratio Pancreatitis, Alcoholic - genetics Pancreatitis, Alcoholic - mortality Pancreatitis, Alcoholic - physiopathology Pancreatitis, Chronic - genetics Pancreatitis, Chronic - mortality Pancreatitis, Chronic - physiopathology Polymorphism, Genetic Polymorphism, Single Nucleotide Reference Values Sex Factors Studies Survival Analysis Trypsin - genetics Trypsinogen - genetics |
| title | Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study |
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