CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats

CYP2C8 is involved in the metabolic clearance of several important drugs and recent reports have shown that acyl glucuronides of gemfibrozil and clopidogrel are potent time-dependent inhibitors of CYP2C8 activity. In the present study, the inhibitory effect of steviol acyl glucuronide (SVAG), a circ...

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Veröffentlicht in:	Food and chemical toxicology 2016-08, Vol.94, p.138-147
Hauptverfasser:	Xu, Yunting, Zhou, Dandan, Wang, Yedong, Li, Jiajun, Wang, Meiyu, Lu, Jia, Zhang, Hongjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbamates - pharmacokinetics Carbamates - pharmacology Chromatography, Liquid CYP2C8 Cytochrome P-450 CYP2C8 - metabolism Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacokinetics Diterpenes, Kaurane - pharmacology Food-drug interaction Glucuronides - chemistry Humans Hydroxylation Male Microsomes, Liver - enzymology Microsomes, Liver - metabolism Paclitaxel - pharmacokinetics Piperidines - pharmacokinetics Piperidines - pharmacology Rats Rats, Sprague-Dawley Repaglinide Reversible inhibition Steviol acyl glucuronide Tandem Mass Spectrometry
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