Altered brain morphology and functional connectivity reflect a vulnerable affective state after cumulative multigenerational stress in rats

Highlights • Multigenerational stress raised stress vulnerability and emotional state in female rats. • Multigenerational stress reduced neuronal density in areas that regulate stress response. • Multigenerational stress altered cortical gene expression related to neuroplasticity. • Greater stress v...

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Veröffentlicht in:	Neuroscience 2016-08, Vol.330, p.79-89
Hauptverfasser:	McCreary, J. Keiko, Truica, L. Sorina, Friesen, Becky, Yao, Youli, Olson, David M, Kovalchuk, Igor, Cross, Albert R, Metz, Gerlinde A.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - growth & development Brain - pathology Brain - physiopathology Cell Count Contrast Media Corticosterone - blood Disease Models, Animal Emotions - physiology Exploratory Behavior - physiology Female Fibroblast Growth Factors - metabolism gene expression Gene Expression Regulation - physiology HPA axis Magnetic Resonance Imaging Manganese manganese-enhanced magnetic resonance imaging multigenerational prenatal stress Neural Pathways - diagnostic imaging Neural Pathways - growth & development Neural Pathways - pathology Neural Pathways - physiopathology Neurology Neurons - pathology Neurons - physiology Pregnancy Prenatal Exposure Delayed Effects Rats, Long-Evans Receptor, EphA5 - metabolism Resilience, Psychological stress resilience Stress, Psychological - physiopathology Synaptosomal-Associated Protein 25 - metabolism T2-relaxometry
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Zusammenfassung:	Highlights • Multigenerational stress raised stress vulnerability and emotional state in female rats. • Multigenerational stress reduced neuronal density in areas that regulate stress response. • Multigenerational stress altered cortical gene expression related to neuroplasticity. • Greater stress vulnerability was linked to altered brain activation in manganese-enhanced MRI.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.05.046