Allograft Vasculopathy: The Achilles' Heel of Heart Transplantation

Cardiac allograft vasculopathy (CAV) remains the Achilles' heel of long-term survival after heart transplantation. Almost one-third of patients develop CAV by 5 years post-transplant and 1 in 8 deaths beyond a year are due to CAV. Abnormal vascular fibroproliferation in CAV occurs as a result o...

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Veröffentlicht in:	Journal of the American College of Cardiology 2016-07, Vol.68 (1), p.80-91
Hauptverfasser:	Chih, Sharon, Chong, Aun Yeong, Mielniczuk, Lisa M, Bhatt, Deepak L, Beanlands, Rob S B
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Cardiology Cardiovascular disease Cell adhesion & migration Cell growth Cytokines Cytomegalovirus Flow velocity Gangrene Heart Heart Transplantation Humans Infections Ischemia Medical imaging Mortality Nitric oxide Postoperative Complications - diagnosis Postoperative Complications - etiology Postoperative Complications - therapy Rodents Smooth muscle Surveillance Transplants & implants Tumor necrosis factor-TNF Vascular Diseases - diagnosis Vascular Diseases - etiology Vascular Diseases - therapy Vascular endothelial growth factor
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