Substrate-Determined Diastereoselectivity in an Enzymatic Carboligation

Thiamine diphosphate‐dependent enzymes catalyze the formation of C−C bonds, thereby generating chiral secondary or tertiary alcohols. By the use of vibrational circular dichroism (VCD) spectroscopy we studied the stereoselectivity of carboligations catalyzed by YerE, a carbohydrate‐modifying enzyme...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-07, Vol.17 (13), p.1207-1210
Hauptverfasser:	Lehwald, Patrizia, Fuchs, Olga, Nafie, Laurence A., Müller, Michael, Lüdeke, Steffen
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon-Carbon Lyases - chemistry chemoselectivity Circular Dichroism conformation analysis Cyclohexanols - chemistry Cyclohexanones - chemistry diastereoselectivity enzyme catalysis Molecular Structure Stereoisomerism tertiary alcohols vibrational circular dichroism Yersinia pseudotuberculosis Yersinia pseudotuberculosis - enzymology
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