In vivo maintenance of human regulatory T cells during CD25 blockade

Regulatory T cells (Tregs) mediate immune tolerance to self and depend on IL-2 for homeostasis. Treg deficiency, dysfunction, and instability are implicated in the pathogenesis of numerous autoimmune diseases. There is considerable interest in therapeutic modulation of the IL-2 pathway to treat auto...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2015-01, Vol.194 (1), p.84-92
Hauptverfasser:	Huss, David J, Mehta, Devangi S, Sharma, Akanksha, You, Xiaojun, Riester, Katherine A, Sheridan, James P, Amaravadi, Lakshmi S, Elkins, Jacob S, Fontenot, Jason D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use CD4 Lymphocyte Count Cell Cycle - drug effects Cell Cycle - genetics Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Humans Immunoglobulin G - therapeutic use Immunosuppressive Agents - therapeutic use Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin Receptor Common gamma Subunit - immunology Interleukin-17 - biosynthesis Interleukin-17 - immunology Interleukin-2 - biosynthesis Interleukin-2 - blood Interleukin-2 - immunology Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors Interleukin-2 Receptor alpha Subunit - immunology Interleukin-2 Receptor beta Subunit - immunology Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - immunology Phosphorylation Promoter Regions, Genetic Self Tolerance - drug effects Self Tolerance - immunology STAT5 Transcription Factor - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!