Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016)

The inside cover picture shows the benefit of 5’‐(E)‐vinylphosphonate (VP), a stable phosphate mimic over 5′‐phosphate (5′‐P) in improving the siRNA‐GalNAc conjugate loading into the RNA‐induced silencing complex (RISC). The siRNA conjugated to trivalent N‐acetylgalactosamine (GalNAc) is recognized...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-06, Vol.17 (11), p.970-970
Hauptverfasser:	Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Format:	Artikel
Sprache:	eng
Schlagworte:	Clp1 kinase oligonucleotides phosphate mimic RISC loading siRNA
Online-Zugang:	Volltext
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