C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation

C-type lectin receptors expressed in APCs are recently defined pattern recognition receptors that play a crucial role in immune responses against pathogen-associated molecular patterns. Among pathogen-associated molecular patterns, cord factor (trehalose-6,6'-dimycolate [TDM]) is the most poten...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-06, Vol.194 (11), p.5366-5374
Hauptverfasser:	Miyake, Yasunobu, Masatsugu, Oh-hora, Yamasaki, Sho
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bone Marrow Cells - immunology Cell Wall - immunology Cells, Cultured Cord Factors - immunology Dendritic Cells - immunology Hydrophobic and Hydrophilic Interactions Lectins, C-Type - genetics Lectins, C-Type - metabolism Lipopolysaccharides - immunology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Mycobacterium Mycobacterium tuberculosis - immunology Protein Interaction Domains and Motifs - immunology Protein Structure, Tertiary Receptors, Immunologic - genetics Receptors, Immunologic - metabolism RNA, Messenger - biosynthesis Signal Transduction Tuberculosis - immunology Zymosan - immunology
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