Iriomoteolides-10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate Amphidinium Species

Two new macrolides, iriomoteolides-10a (1) and -12a (2), have been isolated from a marine dinoflagellate Amphidinium sp. (KCA09053 strain), and their structures were elucidated on the basis of a detailed two dimensional (2D)-NMR analysis. Compound 1 is a novel 21-membered Amphidinium macrolide, whic...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/07/01, Vol.64(7), pp.1019-1023
Hauptverfasser:	Akakabe, Mai, Kumagai, Keiko, Tsuda, Masayuki, Konishi, Yuko, Tominaga, Akira, Kaneno, Daisuke, Fukushi, Eri, Kawabata, Jun, Masuda, Atsunori, Tsuda, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphidinium Animals Cell Line, Tumor Cell Survival - drug effects cytotoxic activity dinoflagellate Dinoflagellida - chemistry Dose-Response Relationship, Drug HeLa Cells Humans macrolide Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Mice Molecular Conformation Structure-Activity Relationship
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