Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients

In mammals, chronic diseases resulting from infectious agents have been associated with functional T cell response deficiency, a high frequency of terminally differentiated T cells, the presence of monofunctional Ag-specific T cells, and increased expression of inhibitory receptors. Similar to other...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-10, Vol.195 (8), p.3748-3758
Hauptverfasser:	Lasso, Paola, Mateus, Jose, Pavía, Paula, Rosas, Fernando, Roa, Nubia, Thomas, M Carmen, López, Manuel C, González, John M, Puerta, Concepción J, Cuéllar, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Protozoan - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Differentiation - immunology Chagas Disease - immunology Chagas Disease - pathology Chronic Disease Female Gene Expression Regulation - immunology Humans Male Middle Aged Receptors, Immunologic - immunology Trypanosoma cruzi Trypanosoma cruzi - immunology
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