Synthesis of the Hemoglobin-Conjugated Polymer Micelles by Thiol Michael Addition Reactions

Amphiphilic triblock copolymers mPEG‐b‐PMAC‐b‐PCL are synthesized using methoxyl poly(ethylene glycol), cyclic carbonic ester monomer including acryloyl group, and ε‐caprolactone. Copolymers are self‐assembled into core–shell micelles in aqueous solution. Thiolated hemoglobin (Hb) is conjugated with...

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Veröffentlicht in:	Macromolecular bioscience 2016-06, Vol.16 (6), p.906-913
Hauptverfasser:	Qi, Yanxin, Li, Taihang, Wang, Yupeng, Wei, Xing, Li, Bin, Chen, Xuesi, Xie, Zhigang, Jing, Xiabin, Huang, Yubin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemistry Aqueous solutions Caproates - chemistry Drug Delivery Systems Hemoglobin Hemoglobins - chemical synthesis Hemoglobins - chemistry Lactones - chemistry Micelles Nanoparticles - chemistry Oxygen - chemistry oxygen carriers Polyethylene Glycols - chemistry protein delivery thiol Michael addition
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