An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics

ABSTRACT There is an urgent unmet need for human tissue bioassays to predict cytokine storm responses to biologics. Current bioassays that detect cytokine storm responses in vitro rely on endothelial cells, usually from umbilical veins or cell lines, cocultured with freshly isolated peripheral blood...

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Veröffentlicht in:	The FASEB journal 2015-06, Vol.29 (6), p.2595-2602
Hauptverfasser:	Reed, Daniel M., Paschalaki, Koralia E., Starke, Richard D., Mohamed, Nura A., Sharp, Giles, Fox, Bernard, Eastwood, David, Bristow, Adrian, Ball, Christina, Vessillier, Sandrine, Hansel, Trevor T., Thorpe, Susan J., Randi, Anna M., Stebbings, Richard, Mitchell, Jane A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alemtuzumab Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized - pharmacology Bevacizumab Biological Assay - methods Biological Products - pharmacology Cell Proliferation - drug effects coculture Coculture Techniques Culture Media - pharmacology Cytokines - metabolism Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme-Linked Immunosorbent Assay Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Interleukin-2 - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism personalized medicine Reproducibility of Results Serum - chemistry stem cells TGN1412 Trastuzumab Tumor Necrosis Factor-alpha - metabolism
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