CD13/aminopeptidase N is a negative regulator of mast cell activation

ABSTRACT Antigen‐induced mast cell (MC) activation via cross‐linking of IgE‐bound high‐affinity receptors for IgE (FcεRI) underlies type I allergy and anaphylactic shock. Comprehensive knowledge of FcεRI regulation is thus required. We have identified a functional interaction between FcεRI and CD13...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2016-06, Vol.30 (6), p.2225-2235
Hauptverfasser:	Zotz, Julia S., Wölbing, Florian, Lassnig, Caroline, Kauffmann, Marlies, Schulte, Uwe, Kolb, Andreas, Whitelaw, Bruce, Müller, Mathias, Biedermann, Tilo, Huber, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis Animals CD13 Antigens - antagonists & inhibitors CD13 Antigens - genetics CD13 Antigens - metabolism Cell Proliferation degranulation Dinitrophenols - immunology Gene Expression Regulation - physiology IgE receptor Leucine - analogs & derivatives Leucine - pharmacology Macrophages Mast Cells - physiology Mice Mice, Inbred C57BL Mice, Knockout passive systemic anaphylaxis proinflammatory cytokines receptor internalization Receptors, IgE - genetics Receptors, IgE - metabolism Serum Albumin - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!