The Prognostic Impact of In-Hospital Change in Mean Platelet Volume in Patients With Non–ST-Segment Elevation Myocardial Infarction

The Prognostic Impact of In-Hospital Change in Mean Platelet Volume in Patients With Non–ST-Segment Elevation Myocardial Infarction

It is unclear whether changes in mean platelet volume (MPV) are associated with total mortality in acute coronary syndromes. We investigated whether the change in MPV predicts total mortality in patients with non–ST-segment elevation myocardial infarction (NSTEMI). We retrospectively analyzed 419 co...

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Veröffentlicht in:Angiology 2016-08, Vol.67 (7), p.690-696
Hauptverfasser: Kırış, Tuncay, Yazici, Selcuk, Günaydin, Zeki Yüksel, Akyüz, Şükrü, Güzelburç, Özge, Atmaca, Hüsnü, Ertürk, Mehmet, Nazli, Cem, Dogan, Abdullah
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container_end_page 696
container_issue 7
container_start_page 690
container_title Angiology
container_volume 67
creator Kırış, Tuncay
Yazici, Selcuk
Günaydin, Zeki Yüksel
Akyüz, Şükrü
Güzelburç, Özge
Atmaca, Hüsnü
Ertürk, Mehmet
Nazli, Cem
Dogan, Abdullah
description It is unclear whether changes in mean platelet volume (MPV) are associated with total mortality in acute coronary syndromes. We investigated whether the change in MPV predicts total mortality in patients with non–ST-segment elevation myocardial infarction (NSTEMI). We retrospectively analyzed 419 consecutive patients (19 patients were excluded). The remaining patients were categorized as survivors (n = 351) or nonsurvivors (n = 49). Measurements of MPV were performed at admission and after 24 hours. The difference between the 2 measurements was considered as the MPV change (ΔMPV). The end point of the study was total mortality at 1-year follow-up. During the follow-up, there were 49 deaths (12.2%). Admission MPV was comparable in the 2 groups. However, both MPV (9.6 ± 1.4 fL vs 9.2 ± 1.0 fL, P = .044) and ΔMPV (0.40 [0.10-0.70] fL vs 0.70 [0.40-1.20] fL, P < .001) at the first 24 hours were higher in nonsurvivors than survivors. In multivariate analysis, ΔMPV was an independent predictor of total mortality (odds ratio: 1.84, 95% confidence interval: 1.28-2.65, P = .001). An early increase in MPV after admission was independently associated with total mortality in patients with NSTEMI. Such patients may need more effective antiplatelet therapy.
doi_str_mv 10.1177/0003319715627734
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title The Prognostic Impact of In-Hospital Change in Mean Platelet Volume in Patients With Non–ST-Segment Elevation Myocardial Infarction
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