A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

Dendritic cells (DC) are the major antigen-presenting cells bridging innate and adaptive immunity, a function they perform by converting quiescent DC to active, mature DC with the capacity to activate naïve T cells. They do this by migrating from the tissues to the T cell area of the secondary lymph...

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Veröffentlicht in:	Journal of molecular cell biology 2015-12, Vol.7 (6), p.517-528
Hauptverfasser:	Martin-Granados, Cristina, Prescott, Alan R, Le Sommer, Samantha, Klaska, Izabela P, Yu, Tian, Muckersie, Elizabeth, Giuraniuc, Claudiu V, Grant, Louise, Delibegovic, Mirela, Forrester, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells Cell Differentiation Cell Movement - physiology Cells, Cultured Chemokine CCL19 - metabolism Coculture Techniques Dendritic Cells - immunology Female Lymphocyte Activation Mice Mice, Knockout Myeloid Cells - enzymology Nuclear Receptor Coactivator 1 - metabolism Podosomes - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - physiology Receptors, CCR7 - metabolism STAT3 Transcription Factor - metabolism T-Lymphocytes - immunology
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