Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

Multiple studies reporting mitochondrial impairment in Parkinson's disease (PD) involve knockout or knockdown models to inhibit the expression of mitochondrial‐related genes, including parkin, PINK1, and DJ‐1 ones. Melatonin has significant neuroprotective properties, which have been related to...

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Veröffentlicht in:	Journal of pineal research 2016-08, Vol.61 (1), p.96-107
Hauptverfasser:	Díaz-Casado, María E., Lima, Elena, García, José A, Doerrier, Carolina, Aranda, Paula, Sayed, Ramy KA, Guerra-Librero, Ana, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío
Format:	Artikel
Sprache:	eng
Schlagworte:	1-methyl-4-phenyl-1 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine 6-tetrahydropyridine Animals Danio rerio Embryo, Nonmammalian - metabolism Melatonin - pharmacology mitochondrial complex I mitochondrial-related genes MPTP Poisoning - drug therapy MPTP Poisoning - genetics MPTP Poisoning - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism parkinson's disease Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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